衰老标记蛋白30对糖尿病心肌病的保护作用及其机制OACSTPCD
Protective effects and mechanism of senescence marker protein 30 against diabetic cardiomyopathy
目的 观察衰老标记蛋白30(SMP30)对糖尿病心肌病(DCM)心肌损伤的保护作用并探讨其机制.方法 采用腹腔注射链脲佐菌素(STZ)联合高脂饮食法建立糖尿病心肌病模型.将40只野生型(WT)C57BL/6小鼠随机分为野生对照组(WT+Con组)和野生糖尿病心肌病组(WT+DCM),每组20只.将40只SMP30转基因(SMP30+/+)小鼠随机分为SMP30+/+对照组(SMP30+/++Con)和SMP30+/+糖尿病心肌病组(SMP30+/…查看全部>>
Objective To observe the protective effect of senescence marker protein 30(SMP30)against diabetic cardiomyopathy and explore its mechanism.Methods A mouse model of diabetic cardiomyopathy was established by intraperitoneal injection of strepto-zotocin(STZ)combined with high fat diet.Forty wild-type(WT)C57BL/6 mice were randomly divided into WT+Con group and WT+DCM group,with 20 mice in each group.Forty SMP30+/+mice were randomly divided into SMP30+/++Con gro…查看全部>>
胡培静;张学丹;杜占奎;屈欣怡;安慧仙;曹彪
西安医学院第二附属医院心血管内科,西安 710005西安医学院第二附属医院心血管内科,西安 710005西安医学院第二附属医院心血管内科,西安 710005西安医学院第二附属医院心血管内科,西安 710005西安国际医学中心医院心内科西安医学院第二附属医院心血管内科,西安 710005
临床医学
衰老标记蛋白30糖尿病心肌病心肌损伤炎症炎症小体细胞焦亡
SMP30diabetic cardiomyopathymyocardial injuryinflammationinflammasomepyroptosis
《山西医科大学学报》 2024 (9)
1144-1153,10
陕西省重点研发计划项目(2023-YBSF-576)
评论