抑郁症与非酒精性脂肪性肝病因果关系的双向孟德尔随机化研究OACSTPCD
Bidirectional Mendelian randomization study on causal relationship between depression and non-alcoholic fatty liver disease
目的 采用两样本孟德尔随机化方法(Mendelian randomization,MR)研究抑郁症(major depression disease,MDD)与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的因果关系.方法 使用公开的全基因组关联研究(Genome-Wide Association Study,GWAS)的汇总数据进行分析,所采用的GWAS汇总数据均来源于欧洲人群.采用逆方差加…查看全部>>
Objective To investigate the causal relationship between major depression disease(MDD)and non-alcoholic fatty liver disease(NAFLD)by two-sample Mendelian randomization(MR)methods.Methods The summary data of the publicly available Genome-Wide Association Study(GWAS)were analyzed.The GWAS summary data were all from the European population.The inverse variance weighted(IVW)method,MR-Egger regression method and weighted median method were used for bidirectional …查看全部>>
艾楠;王馨晨;刘星宇;王锐;杨婧
黑龙江中医药大学基础医学院病理教研室,哈尔滨 150040黑龙江中医药大学基础医学院病理教研室,哈尔滨 150040黑龙江中医药大学基础医学院病理教研室,哈尔滨 150040黑龙江中医药大学药学院药剂教研室黑龙江中医药大学基础医学院病理教研室,哈尔滨 150040
临床医学
孟德尔随机化抑郁症非酒精性脂肪性肝病全基因组关联研究
Mendelian randomizationmajor depression diseasenon-alcoholic fatty liver diseaseGWAS
《山西医科大学学报》 2024 (9)
1163-1169,7
国家自然科学基金资助项目(81603418)黑龙江省优秀青年人才项目(2020YQ05)
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