山西医科大学学报2024，Vol.55Issue(9)：1163-1169,7.DOI:10.13753/j.issn.1007-6611.2024.09.009
抑郁症与非酒精性脂肪性肝病因果关系的双向孟德尔随机化研究
Bidirectional Mendelian randomization study on causal relationship between depression and non-alcoholic fatty liver disease
摘要
Abstract
Objective To investigate the causal relationship between major depression disease(MDD)and non-alcoholic fatty liver disease(NAFLD)by two-sample Mendelian randomization(MR)methods.Methods The summary data of the publicly available Genome-Wide Association Study(GWAS)were analyzed.The GWAS summary data were all from the European population.The inverse variance weighted(IVW)method,MR-Egger regression method and weighted median method were used for bidirectional two-sample MR analysis to evaluate the causal relationship between MDD and NAFLD.Sensitivity analysis was used to evaluate the stability and the reliability of the results.Results The results of positive MR analysis showed a causal relationship between MDD and the risk of NAFLD(IVW:OR=1.307,95%CI 1.051-1.626,P=0.016).Sensitivity analysis results showed no horizontal pleiotropy or heterogenei-ty,and the leave-one-out method results showed that eliminating any single SNP did not affect the overall effect estimate.The re-sults of reverse MR analysis showed no causal relationship between NAFLD and the risk of MDD(P>0.05).Conclusion Mendelian ran-domization results suggest that MDD can increase the risk of NAFLD.关键词
孟德尔随机化/抑郁症/非酒精性脂肪性肝病/全基因组关联研究Key words
Mendelian randomization/major depression disease/non-alcoholic fatty liver disease/GWAS分类
医药卫生引用本文复制引用
艾楠,王馨晨,刘星宇,王锐,杨婧..抑郁症与非酒精性脂肪性肝病因果关系的双向孟德尔随机化研究[J].山西医科大学学报,2024,55(9):1163-1169,7.基金项目
国家自然科学基金资助项目(81603418) （81603418）
黑龙江省优秀青年人才项目(2020YQ05) （2020YQ05）
