山西医科大学学报2024，Vol.55Issue(9)：1228-1237,10.DOI:10.13753/j.issn.1007-6611.2024.09.018
基于多分网络和网络药理学探讨中医治疗类风湿性关节炎的用药规律和作用机制
Medication patterns and mechanism of traditional Chinese medicines in the treatment of rheumatoid arthritis based on mul-ticomponent network and network pharmacology
摘要
Abstract
Objective To systematically analyze the medical cases of Bi syndrome in the Qing dynasty for providing a reference in the treatment of rheumatoid arthritis(RA).Methods Commonly used drugs and common syndromes of Bi syndrome were obtained based on frequency analysis.Based on the assessment of data quality,the binary networks of"prescription-traditional Chinese medicine"and"prescription-syndrome type",and a tripartitic network of"syndrome-drug-prescription"were simultaneously constructed.According to the results,the components and targets of the core Chinese medicines were downloaded from traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP),and the targets were standardized through the UniProt database.RA targets were obtained from the GeneCards database,and the intersection targets were acquired through the Weishengxin platform.Protein-protein interaction networks(PPI)were constructed using STRING database and Cytoscape.Core components and core targets were screened to complete GO and KEGG enrichment analysis.Results In total,347 cases of Bi syndrome in the Qing dynasty were identified,including 203 kinds of drugs and 137 types of syndromes.The top 10 commonly used drugs in terms of frequency were Chinese Angelica,Indian Buead,White Peony Root,Liquorice Root,Rehmanniae Radix,Largehead Atractylodes Rhizomeizome,Baikal Skullcap Root,Szechwan Lovage Rhizome,Nutgrass Galingale Rhizome,and Tangerine Peel.The 11 common syndromes were Qi and Blood deficiency syndrome,Wind-Cold exterior syndrome,Dampness-Dominated Bi syndrome,Qi stagnation syndrome,Dampness-Heat accumulation syndrome,Gan Yin deficiency syndrome,syndrome of Blood failing to nourish sinews,syndrome of dampness and Heat pouring downwards,Exterior Cold and Interior Dampness syndrome,syndrome of Dampness-Heat blocking meridian and collater-als,and syndrome of fluid retention overflowing in limbs.The multi-component network showed that the crucial drug combination con-sisted of Chinese Angelica-White Peony Root-Largehead Atractylodes Rhizome.There were 2 effective components of Chinese An-gelica,13 effective components of White Peony Root and 7 effective components of Largehead Atractylodes Rhizomeizome in treatment of RA.There were 12 key targets for RA,mainly involving MAPK signaling pathway.Conclusion The main directions of medication in the treatment of RA in medical cases are pain relief,dampness-eliminating,tonifying Qi and nourishing Blood.The combination of Chinese Angelica,White Peony Root and Largehead Atractylodes Rhizome has potential therapeutic effects on RA.关键词
多分网络/类风湿性关节炎/清宫医案/网络药理学/用药规律/痹症Key words
multicomponent network analysis/rheumatoid arthritis/medical records of the Qing dynasty/network pharmaco-logy/medication pattern/Bi syndrome分类
医药卫生引用本文复制引用
李琦,李保珍,马艳苗,梁傲雪,吕艳华..基于多分网络和网络药理学探讨中医治疗类风湿性关节炎的用药规律和作用机制[J].山西医科大学学报,2024,55(9):1228-1237,10.基金项目
国家社会科学基金一般项目(20BTQ064) （20BTQ064）
