刑事技术2024，Vol.49Issue(5)：480-484,5.DOI:10.16467/j.1008-3650.2023.0076
多个Y-STR等位基因缺失及AZF分析
Detection of Multiple Y-STRs Allele Dropout and AZF Analysis
摘要
Abstract
In this paper,the characteristics of allele typing deletion of Y-STR loci and its correlation with AZF(azoospermia factor)deletion were discussed,which could provide reference for forensic practice.Y-STR kits(Yfiler Platinum,SureID PathFinder Plus)were used to analyze the blood samples of 23 461 male family members.A total of 14 cases with 4 or more Y-STR allele-dropout samples were found.Meanwhile,Sequence-tagged site(STS)was detected with Y chromosome microdeletion detection kit,and the deletion of AZF region of Y chromosome was evaluated according to the deletion STS.The results showed that the proportion of multiple Y-STR typing missing was 0.059 7%(14/23461),with 1 case of short arm and 13 cases of long arm,which were from different families with different types.STS deletion was detected in the AZF region in 13 long arm multiple typing deletion samples,and no abnormality was detected in 1 short arm multiple typing deletion sample.This study suggests that there is a correspondence between multiple STR allele dropouts in the long arm of Y chromosome and microdeletions in AZF region,and the biological basis of sterility exists in these typing individuals.关键词
法医遗传学/Y-STR/等位基因分型缺失/无精子因子/突变Key words
forensic genetics/Y-STR/allele dropout/AZF/mutation分类
社会科学引用本文复制引用
刘振平,童继军,翟仙敦..多个Y-STR等位基因缺失及AZF分析[J].刑事技术,2024,49(5):480-484,5.基金项目
河南省科技攻关项目(222102310398) （222102310398）
