观察热毒宁注射液联合头孢噻肟钠治疗急性上呼吸道感染患儿临床疗效OA
Clinical Efficacy of Reduning Injection Combined with Cefotaxime Sodium in the Treatment of Acute Upper Respiratory Tract Infection in Children
目的 探究热毒宁注射液联合头孢噻肟钠治疗急性上呼吸道感染患儿的临床疗效.方法 选择 2020 年 12 月至 2022 年 12 月期间在台前县人民医院治疗的 94 例上呼吸道感染患儿,应用随机数字表法将其分为对照组(应用头孢噻肟钠)及观察组(应用头孢噻肟钠联合热毒宁注射液)各 47 例,对比两组患儿症状改善时间、治疗有效率、炎症因子水平、免疫功能、不良反应发生率.结果 观察组退热时间、咳嗽消失时间、鼻塞消失时间、咽痛消失时间短于对照组,差异均有统计学意义(P＜0.05).观察组治疗有效率高于对照组,差异具有统计学意义(P＜0.05).治疗后,两组超敏C反应蛋白(hs-CRP)、血清淀粉样蛋白A(SAA)、降钙素原(PCT)、肿瘤坏死因子(TNF-α)水平均降低,且观察组hs-CRP、SAA、PCT、TNF-α水平低于对照组,差异具有统计学意义(P＜0.05).治疗后,两组CD8+水平降低,CD3+、CD4+、CD4+/CD8+水平升高,且观察组CD8+低于对照组,CD3+、CD4+、CD4+/CD8+高于对照组,差异具有统计学意义(P＜0.05).观察组不良反应发生率低于对照组,差异具有统计学意义(P＜0.05).结论 急性上呼吸道感染患儿采用热毒宁注射液联合头孢噻肟钠治疗,可降低炎症因子水平,改善患儿免疫功能,降低不良反应发生率,促进患儿康复.
Objective To explore the clinical efficacy of Reduning Injection combined with cefotaxime sodium in the treatment of acute upper respiratory tract infection in children.Methods Ninety-four children with acute upper respiratory tract infection treated at Taiqian County People's Hospital from December 2020 to December 2022 were selected and randomly divided into a control group(treated with cefotaxime sodium)and an observation group(treated with cefotaxime sodium combined with Reduning Injection),with 47 cases in each group.The symptom improvement time,treatment efficacy,levels of inflammatory factors,immune function,and incidence of adverse reactions were compared between the two groups.Results The observation group had shorter fever reduction time,cough disappearance time,nasal congestion disappearance time,and sore throat disappearance time compared to the control group,with statistically significant differences(P＜0.05).The treatment efficacy in the observation group was higher than that in the control group,with statistically significant differences(P＜0.05).After treatment,the levels of high-sensitivity C-reactive protein(hs-CRP),serum amyloid A(SAA),procalcitonin(PCT),and tumor necrosis factor-alpha(TNF-α)in both groups decreased,with the observation group showing lower levels than the control group,with statistically significant differences(P＜0.05).After treatment,the levels of CD8+decreased,while the levels of CD3+,CD4+,and CD4+/CD8+increased in both groups,with the observation group showing lower CD8+levels and higher CD3+,CD4+,and CD4+/CD8+levels than the control group,with statistically significant differences(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,with statistically significant differences(P＜0.05).Conclusion The combination of Reduning Injection and cefotaxime sodium in the treatment of acute upper respiratory tract infection in children can reduce the levels of inflammatory factors,improve immune function,reduce the incidence of adverse reactions,and promote recovery.
李爱平;刘敏
台前县人民医院 儿二科,河南 濮阳 457600
临床医学
热毒宁注射液头孢噻肟钠急性上呼吸道感染患儿体征改善炎症因子
Reduning injectioncefotaxime sodiumacute upper respiratory tract infectionsymptom improvement in childreninflammatory factors
《临床研究》 2024 (010)
124-127 / 4
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