"醒脑开窍"针刺法对脑缺血再灌注损伤大鼠铁死亡相关因子表达的影响OA北大核心CSTPCDMEDLINE
Effect of"Xingnao Kaiqiao"needling on expression of ferroptosis-related factors in rats with cerebral ischemia-reperfusion injury
目的:观察"醒脑开窍"针刺法对脑缺血再灌注损伤(CIRI)大鼠神经元铁死亡相关蛋白表达的影响,探讨针刺抑制CIRI大鼠神经元铁死亡的作用机制.方法:将雄性Wistar大鼠随机分为假手术组、模型组、针刺组和去铁胺(DFO)组,每组18只.采用线栓法制备CIRI大鼠模型,针刺组予针刺"水沟""内关""三阴交",每日针刺2次,每次20 min,连续3 d.DFO组腹腔注射DFO注射液(0.1 g/kg),每日1次,连续3 d.采用Zausinger 6…查看全部>>
Objective To observe the effect of"Xingnao Kaiqiao"needling on the expression of ferroptosis-related proteins in neurons of rats with cerebral ischemia-reperfusion injury(CIRI),so as to explore its mechanism underlying improvement of CIRI.Methods Male Wistar rats were randomly divided into sham operation,model,acupuncture and deferoxamine(DFO)groups,with 18 rats in each group.The CIRI model was established by occlusion of the middle cerebral artery.In the ac…查看全部>>
王琪;刘瑶瑶;侯子文
天津中医药大学第一附属医院,天津 300193||国家中医针灸临床医学研究中心,天津 300193天津中医药大学,天津 301617天津中医药大学,天津 301617
"醒脑开窍"针刺法脑缺血再灌注损伤铁死亡氧化应激
"Xingnao Kaiqiao"needlingCerebral ischemia reperfusion injuryFerroptosisOxidative stress
《针刺研究》 2024 (10)
1019-1029,11
国家自然科学基金青年项目(No.82104995)
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