中国免疫学杂志2024，Vol.40Issue(9)：1986-1991,6.DOI:10.3969/j.issn.1000-484X.2024.09.032
CD133在肿瘤免疫逃逸及诊断的研究进展
Advances of CD133 in immune escape and diagnosis of tumor
摘要
Abstract
Cancer stem cells(CSCs)are a small group of cells found in tumors that have same self-renewing properties as nor-mal stem cells.In recent years,with continuous development of science and technology in various aspects,people's research on tumor diseases has been deepened.CSCs has been defined as a key factor in promoting tumor development,especially participating in pro-moting tumor recurrence,metastasis,chemotherapy resistance,etc.Currently,CD133 has become one of popular CSCs markers,and can be highly expressed in a variety of CSCs.CD133 is closely related to diagnosis of cancer diseases,and plays an important role in dignosis and drug targeting for gastric cancer,lung cancer,brain tumor,liver cancer,ovarian cancer and colorectal cancer.This article reviews structure,function,immune mechanism escape of CD133,signal pathway of CD133 in tumorigenesis,and correlation of CD133 with various tumors as well.关键词
CD133/免疫逃逸/肿瘤干细胞/标志物Key words
CD133/Immune escape/Tumor stem cells/Marker分类
医药卫生引用本文复制引用
陈多多,胡迪,刘冰清,李琦,王弘瑞,杨明..CD133在肿瘤免疫逃逸及诊断的研究进展[J].中国免疫学杂志,2024,40(9):1986-1991,6.基金项目
国家自然科学基金青年科学基金(81902111). （81902111）
