中国免疫学杂志2024，Vol.40Issue(9)：2011-2016,后插1-后插2,8.DOI:10.3969/j.issn.1000-484X.2024.09.036
内质网应激在免疫细胞中的作用研究进展
Research progress of endoplasmic reticulum stress in immune cells
摘要
Abstract
Immune response occurs in a variety of cellular stresses that severely disrupt function of endoplasmic reticulum(ER),leading to accumulation of misfolded or unfolded protein in ER lumen,resulting in endoplasmic reticulum stress(ERS).ERS triggers unfolded protein response to restore ER homeostasis,but its duration is too long and can lead to cell apoptosis.Although sus-tained ERS can lead to an increase in pro-inflammatory cytokines that induce inflammatory responses and activate immune responses,causal relationship between ERS and immune responses has not been established.This review summarizes role of ERS in inducing im-mune cell differentiation,cytokine expression and immune function,and further illustrates regulatory role of ERS in pathogenesis of immune disorders,which is helpful to explore new therapies for ERS-related diseases.关键词
内质网应激/免疫细胞/免疫紊乱/新疗法Key words
Endoplasmic reticulum stress/Immune cells/Immune disorders/New therapies分类
医药卫生引用本文复制引用
卢桃,张茵,李川,林世德..内质网应激在免疫细胞中的作用研究进展[J].中国免疫学杂志,2024,40(9):2011-2016,后插1-后插2,8.基金项目
国家自然科学基金(81860114). （81860114）
