单孔法腔镜保乳术对女性早期乳腺癌患者的影响OA

Objective To investigate the impact of single-port endoscopic breast-conserving surgery on breast aesthetics and stress response indicators in female patients with early-stage breast cancer.Methods A total of 109 patients with unilateral early-stage breast cancer who were treated at Pingdingshan First People's Hospital from January 2023 to December 2023 were selected as the study subjects.According to the random number table method,all patients were divided into a control group(55 patients)and an observation group(54 patients).The control group underwent open breast-conserving surgery,while the observation group underwent single-port endoscopic breast-conserving surgery.Perioperative indicators(operation time,blood loss,average incision length,postoperative drainage volume,postoperative hospital stay)were compared between the two groups.The cancer treatment efficacy at 6 weeks post-operation was compared between the two groups.Serum tumor markers[carcinoembryonic antigen(CEA),tumor-specific growth factor(TSGF),cancer antigen 153(CA153)]before and 1 month after surgery were compared between the two groups.Stress indicators[procalcitonin(PCT),tumor necrosis factor-α(TNF-α),superoxide dismutase(SOD),cortisol(Cor)]before and 3 days after surgery were compared between the two groups.The breast cosmetic outcomes after surgery were also compared between the two groups.Results The operation time,blood loss,average incision length,postoperative drainage volume,and postoperative hospital stay in the observation group were significantly lower than those in the control group,with statistically significant differences(P＜0.05).At 6 weeks post-operation,there were no statistically significant differences in the effective rate and disease control rate between the two groups(P＞0.05).One month after surgery,the levels of CEA,TSGF,and CA153 in both groups were significantly lower than before surgery,with statistically significant differences(P＜0.05).There were no statistically significant differences in the levels of CEA,TSGF,and CA153 between the two groups before and 1 month after surgery(P＞0.05).There were no statistically significant differences in the levels of PCT,TNF-α,SOD,and Cor between the two groups before surgery(P＞0.05).Three days after surgery,the levels of PCT,TNF-α,and Cor in both groups were higher than before surgery,while the levels of SOD were lower than before surgery,with statistically significant differences(P＜0.05).Three days after surgery,the levels of PCT,TNF-α,and Cor in the observation group were significantly lower than those in the control group,while the level of SOD was significantly higher than that in the control group,with statistically significant differences(P＜0.05).The breast cosmetic outcomes in the observation group were significantly better than those in the control group,with statistically significant differences(P＜0.05).Conclusion For patients with early-stage breast cancer,both open breast-conserving surgery and single-port endoscopic breast-conserving surgery can achieve satisfactory short-term cancer control effects.However,single-port endoscopic breast-conserving surgery shows lower invasiveness,accelerates postoperative recovery,reduces patient stress response,and has significant advantages in maintaining breast aesthetics.