中国免疫学杂志2024，Vol.40Issue(10)：2017-2030,14.DOI:10.3969/j.issn.1000-484X.2024.10.001
免疫系统人源化小鼠及其在肿瘤免疫治疗中的应用
Humanized immune system mouse model and its application in tumor immunotherapy
王陈昆 1刘浩飞2
作者信息
- 1. 中国科学院苏州纳米技术与纳米仿生研究所,纳米生物医学部纳米-生物界面重点实验室,类器官创新中心,苏州 215123
- 2. 中国科学院苏州纳米技术与纳米仿生研究所,纳米生物医学部纳米-生物界面重点实验室,类器官创新中心,苏州 215123||中国科学技术大学纳米技术与纳米仿生学院,合肥 230026
- 折叠
摘要
Abstract
Effectiveness of tumor immunotherapy is largely evaluated based on mouse models.Due to species differences,traditional mouse models cannot mirror condition of immune response in human body,resulting in vast majority of mouse-based achievements are not applicable to humans.In recent years,with emergence of immunodeficient mice and its improvement,humanized immune system mouse models based on immunodeficient mice are expected to help us overcome this barrier.We highlight the latest advances and barriers in generation of immunodeficient mice and humanized mouse models,as well as application of humanized mouse models on tumor immune,with aim of providing a guide for their application to tumor immunotherapy studies with potential for clinical translation.关键词
免疫缺陷小鼠/免疫系统人源化小鼠/肿瘤/免疫治疗Key words
Immunodeficient mice/Humanized immune system mouse model/Tumor/Immunotherapy分类
医药卫生引用本文复制引用
王陈昆,刘浩飞..免疫系统人源化小鼠及其在肿瘤免疫治疗中的应用[J].中国免疫学杂志,2024,40(10):2017-2030,14.
