多奈哌齐联合美多芭对帕金森病大鼠神经细胞凋亡及认知功能的影响OA北大核心CSTPCD
Impacts of donepezil combined with Madopar on neuronal apoptosis and cognitive function in Parkinson's disease rats
目的:探究多奈哌齐联合美多芭对帕金森病(PD)大鼠神经细胞凋亡及认知功能的影响及其可能的作用机制.方法:造模成功的PD大鼠分为模型组(生理盐水)、美多芭组(11.0 mg/kg美多芭)、多奈哌齐组(0.6 mg/kg盐酸多奈哌齐)、多奈哌齐+美多芭组(11.0 mg/kg美多芭+0.6 mg/kg盐酸多奈哌齐),另取12只大鼠作为假手术组(生理盐水).评估各组大鼠运动功能、认知功能;免疫组化检测酪氨酸羟化酶(TH)阳性表达;Western blo…查看全部>>
Objective:To explore the impacts and possible mechanism of donepezil combined with Madopar on neuronal apop-tosis and cognitive function in Parkinson's disease(PD)rats.Methods:The PD rats with successful modeling were grouped into model group(normal saline),Madopar group(11.0 mg/kg Madopar),donepezil group(0.6 mg/kg donepezil hydrochloride),and donepezil+Madopar group(11.0 mg/kg Medopa+0.6 mg/kg donepezil hydrochloride),another 12 rats were taken as the sham…查看全部>>
鲁立颖;王琳
天津市北辰医院神经内科,天津 300400天津市北辰医院神经内科,天津 300400
临床医学
多奈哌齐美多芭帕金森病凋亡认知功能PI3K/AKT通路
DonepezilMadoparParkinson's diseaseApoptosisCognitive functionPI3K/AKT pathway
《中国免疫学杂志》 2024 (10)
2064-2070,7
北辰区卫健系统科技项目(SHGY-2021019).
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