中国实用外科杂志2024，Vol.44Issue(9)：988-991,995,5.DOI:10.19538/j.cjps.issn1005-2208.2024.09.04
精准外科范式引导下的肝癌介入放射治疗新理念和新技术
New concepts and technologies in interventional radiotherapy for hepatocellular carcinoma guided by the paradigm of precision surgery
摘要
Abstract
Under the paradigm of precision surgery,interventional radiotherapy for hepatocellular carcinoma(HCC),particularly Yttrium-90 selective internal radiation therapy(SIRT),is becoming a key treatment modality.HCC,a highly malignant gastrointestinal tumor,poses significant public health challenges due to its high incidence and mortality rates.Surgical resection is an effective curative treatment for HCC,but most advanced HCC patients are unresectable when diagnosed.Yttrium-90 SIRT achieves high-dose precision radiation"from the inside out"by directly injecting yttrium-90 microspheres into the tumor-feeding arteries.The success of this technique relies on precise preoperative assessment and planning,accurate intraoperative procedures,and meticulous postoperative management and monitoring to ensure treatment efficacy and safety.Yttrium-90 SIRT can reduce tumor size,increase residual liver volume and eliminate portal vein tumor thrombus,playing an important role in the downgrading treatment of HCC,creating surgical resection opportunities for unresectable tumors,thereby improving long-term survival rates.Under the guidance of precision surgery,the efficacy and safety of interventional radiation therapy for HCC will be better optimized via furtherly standardized and innovative applications.With the collaboration of a multidisciplinary team(MDT),individualized treatment plans,and standardized intraoperative procedures,yttrium-90 SIRT holds broad prospects in HCC management.In the future,as clinical experience accumulates and technology advances,yttrium-90 SIRT is expected to play an increasingly important role in improving HCC cure rates,optimizing treatment processes,reducing side effects,and improving quality of life.关键词
精准外科/肝癌/选择性内放射治疗/钇90Key words
precision surgery/hepatocellular carcinoma/selective internal radiation therapy/Yttrium-90分类
医药卫生引用本文复制引用
董家鸿,张琳,冯晓彬..精准外科范式引导下的肝癌介入放射治疗新理念和新技术[J].中国实用外科杂志,2024,44(9):988-991,995,5.基金项目
国家自然科学基金重点项目(No.81930119) （No.81930119）
中国医学科学院医学与健康科技创新工程创新单元项目(No.2019-I2M-5-056) （No.2019-I2M-5-056）
