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肝癌介入治疗的精准选择与合理应用OA北大核心CSTPCD

Interventional oncology on liver cancer:precisely selection and application

中文摘要英文摘要

肝癌介入治疗在中晚期肝癌的管理中具有重要地位,涵盖了经动脉化疗栓塞(TACE)、选择性内放疗(SIRT)、经肝动脉灌注化疗(HAIC)、射频消融(RFA)、微波 消融(MWA)等多种技术.这些技术的合理应用能够在不同分期的肝癌治疗中发挥关键作用.近年来,精细化TACE概念逐渐被接受,通过精准操作提高疗效并减少不良反应,同时应对"TACE抵抗"现象需要及时调整治疗策略,以改善病人的预后.我国在肝癌介入治疗技术上取得了创新进展,如125I粒子支架和多功能微球的研发,为肝癌治疗提供了新的技术选择,提升了治疗效果.在未来实践中,TACE与靶向治疗和免疫治疗的联合应用被认为是治疗晚期肝癌的有效模式,能够改善肿瘤的局部免疫微环境,提高整体治疗效果.通过这些创新和联合治疗策略,肝癌的介入治疗将能够为病人带来更好的生存获益,并推动肝癌治疗的进一步发展.

Interventional therapy for hepatocellular carcinoma(HCC)plays a crucial role in managing intermediate and advanced stages of the disease.It encompasses various techniques,including transarterial chemoembolization(TACE),selective internal radiation therapy(SIRT),hepatic arterial infusion chemotherapy(HAIC),radiofrequency ablation(RFA),and microwave ablation(MWA).The rational application of these techniques is essential for effective treatment across different stages of HCC.In recent years,the concept of refined TACE has gained acceptance,emphasizing precision in procedures to enhance therapeutic efficacy and minimize adverse effects.Addressing TACE resistance by promptly adjusting treatment strategies is necessary to optimize patient outcomes.China has made innovative advances in interventional therapy for HCC,such as the development of 125I seed stents and multifunctional microspheres,offering new technological options that improve treatment outcomes.In future practice,combining TACE with targeted therapy and immunotherapy is considered an effective approach for treating advanced HCC,and capable of modulating the local immune microenvironment of tumors and enhancing overall treatment efficacy.These innovations and combined therapeutic strategies can improve patient survival and advance the development of HCC treatment.

滕皋军

东南大学附属中大医院介入诊疗与血管外科,江苏南京 210009

临床医学

肝癌介入治疗经动脉化疗栓塞射频消融免疫治疗靶向治疗125I粒子支架经动脉化疗栓塞抵抗

hepatocellular carcinomainterventional therapytransarterial chemoembolizationradiofrequency ablationimmunotherapytargeted therapy125I seed stentTACE resistance

《中国实用外科杂志》 2024 (009)

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国家自然科学基金重点项目(No.82130060);国家重点研发计划变革性技术项目(No.2018YFA0704100);江苏省"十四五"科教能力提升工程医学创新中心项目(No.CXZX202219);南京市科技局生命健康科技专项医工结合项目(No.202205045)

10.19538/j.cjps.issn1005-2208.2024.09.05

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