中国免疫学杂志2024，Vol.40Issue(10)：2202-2206,2213,6.DOI:10.3969/j.issn.1000-484X.2024.10.031
铁死亡通路在类风湿关节炎中的研究进展
Research progress of ferroptosis pathway in rheumatoid arthritis
摘要
Abstract
Rheumatoid arthritis(RA)is a common chronic autoimmune disease with synovitis as its pathological basis and erosive arthritis as its main symptom.Pathogenesis of RA is complex,combination of genetic factors,environmental factors,immune cells,cytokines and autoantibodies causes joint injury,bone destruction and multi-system disease of RA.However,the above mecha-nisms can not fully explain the poor prognosis,high disability rate and poor clinical treatment effect of RA.Therefore,exploring new pathogenesis and therapeutic targets of RA is the focus of RA research.In recent years,with the deepening of RA research,it has been found that there is a new form of cell death in pathological process of RA,namely ferroptosis.Ferroptosis is a type of cell death caused by inhibition of glutathione peroxidase activity and accumulation of lipid reactive oxygen species.Previous studies have con-firmed the close correlation between RA and ferroptosis,this paper mainly explores ferroptosis-related signal pathways that affect the change and development of RA disease from the perspective of regulating the main signal pathways of ferroptosis,so as to find new therapeutic targets for RA and new therapeutic ideas for research.关键词
铁死亡通路/类风湿关节炎/铁过载/炎症Key words
Ferroptosis pathway/Rheumatoid arthritis/Iron overload/Inflammation分类
医药卫生引用本文复制引用
程丽丽,尚双双,戈扬,汤忠富,徐昌萍,李明,黄传兵..铁死亡通路在类风湿关节炎中的研究进展[J].中国免疫学杂志,2024,40(10):2202-2206,2213,6.基金项目
国家自然科学基金(81473672,82104782) （81473672,82104782）
安徽省高校自然科学研究基金重点项目(KJ2020A0395,KJ2021A0556) （KJ2020A0395,KJ2021A0556）
安徽省高校协同创新项目(GXXT-2021-085) （GXXT-2021-085）
安徽省红十字基金会中医药传承创新发展研究项目(2021ZYZD03) （2021ZYZD03）
安徽中医药大学2021年度校级探索性科研项目(2021zxts49) （2021zxts49）
安徽中医药大学2020年度校级科学研究自筹经费项目(2020yfyzc46). （2020yfyzc46）
