中国实用外科杂志2024，Vol.44Issue(9)：1015-1021,7.DOI:10.19538/j.cjps.issn1005-2208.2024.09.10
基于肿瘤微环境的肝细胞癌分子病理分型及其免疫治疗策略
Molecular pathological subtypes of hepatocellular carcinoma based on tumor microenvironment and their immunotherapy strategies
摘要
Abstract
The tumor microenvironment(TME)is the cornerstone and core of immunotherapy for hepatocellular carcinoma(HCC).HCC is highly heterogeneous,with significant differences in molecular pathological features between different etiologies and individuals.HCC lacks targetable driver genes and driver gene-guided targeted therapies,making TME an important entry point for integrating and classifying these diverse patients.Based on TME,HCC can be classified into inflammatory and non-inflammatory subtypes.Patients with inflammatory HCC can potentially benefit from monotherapy or combination therapy with immune checkpoint inhibitors(ICIs),while non-inflammatory patients require combination therapy with ICIs and angiogenesis inhibitors or tyrosine kinase inhibitors(TKIs)to enhance efficacy.Additionally,potential therapeutic strategies still in the experimental stage include targeting specific molecular pathways such as Wnt/β-catenin,and strategies to convert cold tumors into hot tumors by promoting T cell activation and expansion through immunoadjuvants,oncolytic viruses,tumor vaccines,radiotherapy,and chemotherapy.Adoptive cell therapies,especially chimeric antigen receptor T-cell(CAR-T)therapy,have shown great potential in the treatment of HCC.Furthermore,antibody-drug conjugates(ADCs)combined with immunotherapy and bispecific antibody therapies are promising new directions for future treatment development.关键词
肝细胞癌/分子特征/病理学特征/肿瘤微环境/免疫治疗Key words
hepatocellular carcinoma/molecular characteris-tics/pathological characteristics/tumor microenvironment/im-munotherapy分类
医药卫生引用本文复制引用
高强,刘羽鸣..基于肿瘤微环境的肝细胞癌分子病理分型及其免疫治疗策略[J].中国实用外科杂志,2024,44(9):1015-1021,7.基金项目
国家自然科学基金项目(No.81961128025) （No.81961128025）
