中国免疫学杂志2024，Vol.40Issue(10)：2214-2218,5.DOI:10.3969/j.issn.1000-484X.2024.10.033
MFG-E8调节小胶质细胞功能的研究进展
Research progress on role of MFG-E8 in regulating function of microglia
摘要
Abstract
Microglia are resident immune cells in the central nervous system(CNS),it play an important role in both physio-logical and pathological conditions of the CNS,and can be activated by a variety of physicochemical factors to produce pro-inflammato-ry phenotype(M1 type)and anti-inflammatory phenotype(M2 type).Milk fat globule epidermal growth factor 8(MFG-E8)is closely related to the biological function of microglia,which can regulate microglia neuroprotective effects such as promoting phagocytosis,anti-inflammatory,and inhibiting oxidative stress in CNS related diseases.It also regulates microglia pro-tumor effect,which in turn affects the outcome of the disease.This article reviews the role of targeting MFG-E8 in regulating the function of microglia,and provides a basis for finding therapeutic targets for CNS related diseases in the future.关键词
小胶质细胞/MFG-E8/神经保护作用/促肿瘤Key words
Microglia/MFG-E8/Neuroprotection/Tumor-promoting分类
医药卫生引用本文复制引用
董颖,苏刚,高娟,柴苗,王禾,张振昶..MFG-E8调节小胶质细胞功能的研究进展[J].中国免疫学杂志,2024,40(10):2214-2218,5.基金项目
国家自然科学基金面上项目(31870335) （31870335）
甘肃省科技厅自然科学基金(20JR5RA344) （20JR5RA344）
兰州市科技发展指导性计划项目(2019-ZD-51) （2019-ZD-51）
兰州大学第二医院"萃英科技创新"计划项目(CY2021-MS-B01). （CY2021-MS-B01）
