中国免疫学杂志2024，Vol.40Issue(10)：2229-2235,7.DOI:10.3969/j.issn.1000-484X.2024.10.036
细胞自噬在胰腺炎症及纤维化中的研究进展
Research progress of autophagy in pancreatic inflammation and fibrosis
摘要
Abstract
Chronic pancreatitis(CP)is a progressive fibroinflammatory disease characterized by destruction of pancreatic aci-nar cells,infiltration of inflammatory cells,activation of pancreatic stellate cell(PSC),and pancreatic fibrosis.Autophagy partici-pates in the maintenance of cell homeostasis.Recent studies have shown that autophagy closely related to the occurrence and develop-ment of CP.However,several autophagy types in the pancreatic microenvironment play different roles in the progression of CP.The autophagy of acinar cells has a"double-edged sword"effect.PSC autophagy is positively correlated with its activation,while the role of autophagy of inflammatory cells is still unclear.This study focused on some key cells in the CP microenvironment and explored the role and mechanism of autophagy in the progression of CP.关键词
慢性胰腺炎/胰腺纤维化/自噬/腺泡细胞/胰腺星状细胞/巨噬细胞Key words
Chronic pancreatitis/Pancreatic fibrosis/Autophagy/Acinar cells/Pancreatic stellate cell/Macrophage分类
医药卫生引用本文复制引用
高合,许小凡,段丽芳,张红..细胞自噬在胰腺炎症及纤维化中的研究进展[J].中国免疫学杂志,2024,40(10):2229-2235,7.基金项目
国家自然科学基金(82174201,82104815) （82174201,82104815）
陕西中医药大学创新团队项目(2019-YL14) （2019-YL14）
陕西省特支计划(303/141020047). （303/141020047）
