新医学2024，Vol.55Issue(9)：693-700,8.DOI:10.3969/j.issn.0253-9802.2024.09.003
反复种植失败与复发性流产的病因比较
Comparison of the etiological composition between recurrent implantation failure and recurrent pregnancy loss
摘要
Abstract
Objective To explore the differences of etiology of recurrent implantation failure(RIF)and recurrent pregnancy loss(RPL).Methods Patients with RIF(n=315)and patients with RPL(n=376)admitted to the Reproductive Center of the First Affiliated Hospital of Sun Yat-sen University from June 2018 to June 2021 were included.General and etiological data were collected to compare the differences in baseline data and etiological composition.Relative risk factors of the etiology of these two conditions were identified by multivariate regression analysis.Results Univariate analysis showed a significantly higher proportion of chronic endometritis,endometrial polyps,endometriosis,endometriosis complicated with polyps,diminished ovarian reserve and a significantly lower proportion of unexplained cause in the RIF group than in the RPL group(all P<0.05).Multivariate logistic regression analysis showed that the incidence of chronic endometritis(OR=3.044,95%CI 1.849-5.011,P<0.001),endometrial polyps(OR=3.769,95%CI 1.670-8.510,P<0.001),endometriosis(OR=3.812,95%CI 2.131-6.819,P<0.001)and diminished ovarian reserve(OR=2.175,95%CI 1.285-3.683,P=0.004)in the RIF group was significantly higher than that in the RPL group.The proportion of patients with lower anti-Mullerian hormone levels(OR=0.917,95%CI 0.864-0.973,P=0.004)in the RIF group was higher compared with that in the RPL group.Conclusion Chronic endometritis,endometrial polyps,endometriosis,decreased anti-Mullerian hormone level and diminished ovarian reserve are more common in RIF patients,and the screening and monitoring of the above lesions should be strengthened in the subsequent practice of assisted reproduction.关键词
反复种植失败/复发性流产/病因/慢性子宫内膜炎/子宫内膜息肉/子宫内膜异位症/抗米勒管激素Key words
Recurrent implantation failure/Recurrent pregnancy loss/Etiology/Chronic endometritis/Endometrial polyps/Endometriosis/Anti-Müllerian hormone引用本文复制引用
胡奕芳,杨宇欣,王灿,钟雪,梁玉莲,龙姝辰,陈雪儿,叶玉津,王琼..反复种植失败与复发性流产的病因比较[J].新医学,2024,55(9):693-700,8.基金项目
广东省自然科学基金(2021A1515010290) （2021A1515010290）
广州市科技计划重点研发计划(202206010003) （202206010003）
