新医学2024，Vol.55Issue(9)：738-744,7.DOI:10.3969/j.issn.0253-9802.2024.09.009
拷贝数变异在卵巢癌中的研究进展
Research progress in copy number variation in ovarian cancer
摘要
Abstract
Genetic variation is one of the important factors leading to the incidence and development of cancer.Copy number variation is an important source of genetic diversity,which can be expressed as gene amplification or deletion in structure,and is related to the occurrence and development of different tumors.High-throughput sequencing and gene chip technology can be adopted to detect the variation of copy number,and provide relevant information about tumor molecular characteristics,prognosis and treatment,which is conducive to more accurate diagnosis and treatment decisions for patients in clinical practice.Ovarian cancer is one of the female reproductive system diseases with the highest mortality rate.Understanding its pathogenesis is of significance for improving the survival rate of ovarian cancer.At present,the specific role and mechanism of copy number variation in ovarian cancer are still unclear.In this article,relevant copy number variation in ovarian cancer was reviewed based on the existing research results,aiming to provide novel ideas and methods for the prevention,diagnosis and treatment of ovarian cancer.关键词
拷贝数变异/卵巢肿瘤/高通量测序/基因芯片/遗传变异Key words
Copy number variation/Ovarian cancer/High-throughput sequencing/Gene chip/Genetic variation引用本文复制引用
孙梦娜,徐盈,任晨璐,闫雨帆,陈志浩,杨红..拷贝数变异在卵巢癌中的研究进展[J].新医学,2024,55(9):738-744,7.基金项目
国家自然科学基金(82172993) （82172993）
陕西省创新平台(2023PT-07) （2023PT-07）
