新医学2024，Vol.55Issue(9)：745-750,6.DOI:10.3969/j.issn.0253-9802.2024.09.010
促血小板生成素调控慢性肝病患者血小板的作用及其临床应用
Recent advance of pathogenesis of TPO in thrombocytes and its clinical use in patients with chronic liver disease
摘要
Abstract
Patients with chronic liver disease frequently exhibit thrombocytopenia,the etiology of which is intricate and not yet fully understood.As research into the association between chronic liver disease and thrombocytopenia has progressed in recent years,investigators have recognized that the thrombocytopenia in these patients is not solely attributed to splenic hyperfunction but is also modulated to a certain extent by thrombopoietin(TPO).The article posits the possibility of a"liver-derived thrombopoietin-centered gut-liver regulatory network mechanism",providing a comprehensive review of the role of TPO in platelet regulation,the biological functions of platelets in patients with chronic liver disease,the diagnostic implications of TPO in chronic liver disease and cirrhosis,and the therapeutic applications of TPO and TPO receptor agonists in the treatment of thrombocytopenia in chronic liver disease.This review offers novel insights for both basic science and clinical research.关键词
促血小板生成素/慢性肝病/肝硬化/血小板/促血小板生成素受体激动剂Key words
Thrombopoietin/Chronic liver disease/Cirrhosis/Platelet/Thrombopoietin receptor agonists引用本文复制引用
皮赛男,李亮,杨默,陈友鹏..促血小板生成素调控慢性肝病患者血小板的作用及其临床应用[J].新医学,2024,55(9):745-750,6.基金项目
广东省基础与应用基础研究基金项目(2021A1515111034) （2021A1515111034）
深圳市科技计划项目(JCYJ20190809180211430,JCYJ-20190809180213349) （JCYJ20190809180211430,JCYJ-20190809180213349）
