新医学2024，Vol.55Issue(9)：751-756,6.DOI:10.3969/j.issn.0253-9802.2024.09.011
circRNA在慢性粒细胞白血病作用的研究进展
Research progress on the role of circRNA in chronic myelogenous leukemia
摘要
Abstract
Circular RNAs(circRNA)are a class of multifunctional non-coding RNAs with a covalently ring structure,playing a variety of biological roles within cells.Chronic myelogenous leukemia(CML)is a myeloproliferative disorder originating from hematopoietic stem cells and progenitor cells.Although the current research on circRNA in CML is not yet comprehensive,evidence has shown that circRNA plays a significant role in the onset and progression of CML.This review summarizes the involvement of circRNA in CML,particularly focusing on its contribution to tyrosine kinase inhibitors(TKIs)resistance,and discusses the potential utility of circRNA for diagnosing and assessing prognosis in CML.The objective is to provide researchers with an up-to-date overview of the role of circRNA in CML and offer references for future research endeavors.关键词
环状RNA/慢性粒细胞白血病/酪氨酸激酶抑制剂/伊马替尼耐药Key words
circRNA/Chronic myeloid leukemia/Tyrosine kinase inhibitors/Imatinib resistance引用本文复制引用
孙璇,蒋慧,常伟..circRNA在慢性粒细胞白血病作用的研究进展[J].新医学,2024,55(9):751-756,6.基金项目
武汉市卫生计生委医学科研项目(WX21C23) （WX21C23）
