干燥综合征合并肺间质病变住院患者中医证候分布及处方规律研究OACSTPCD

Objective To analyze the TCM syndrome distribution and prescription law of inpatients with Sjögren syndrome(SS)complicated by lung interstitial disease(ILD)using data mining methods.Methods The clinical data of SS-ILD inpatients who met the screening criteria from January 2010 to December 2021 at Guang'anmen Hospital,China Academy of Chinese Medical Sciences were collected.A statistical analysis of TCM syndrome type and basic information,clinical manifestation,tongue and pulse,laboratory examination,TCM prescription and so on was conducted.Results Totally 87 patients were included.There was no significant difference in gender,age,age of onset,disease course or smoking history across patients with distinct syndrome types.Patients with syndrome of combination of dryness and dampness had the highest probability of drinking history(P<0.05).There were substantial differences between syndrome types in the major complaints of xerostomia,joint swelling and pain,chest tightness,cough and joint swelling(P<0.05),but no significant differences in ILD special symptoms,tongue or pulse.The level of urea nitrogen was highest in patients with yin deficiency internal heat syndrome(P<0.05),with no significant difference in other laboratory data.There were 79 prescriptions and 217 kinds of Chinese materia medica in total.High-frequency medications were primarily used to strengthen the spleen and replenish qi,nourish yin and clear heat,nourish blood and promote blood circulation,mainly with neutral property,sweet taste,the main meridians were lung meridians,liver meridians and spleen meridians.The commonly used medicine matched the pathogenesis of deficiency and excess,and the core prescription was a modified combination of Bazhen Decoction and Yangyin Qingfei Decoction.Conclusion The TCM syndrome of SS-ILD is a mixture of deficiency and excess,with qi and yin deficiency as the foundation,turbid phlegm and blood stasis as the superficiality,lung,liver and spleen as the disease's locations.Clinical treatment of replenishing qi and nourishing yin,resolving phlegm,removing blood stasis,and dredging collaterals should be the general guidance.