纳米材料在缺血性卒中诊疗中的研究进展及挑战OA北大核心CSTPCD

Stroke is a major cause of death and long-term disability among residents in China.Traditional therapeutic drugs are limited by the obstruction of the blood-brain barrier,poor stability,lack of targeting,and low drug loading,which may result in suboptimal treatment outcomes.Nanomaterials,as an emerging,non-invasive,and real-time controllable drug delivery system,have been widely used in the diagnosis and treatment of stroke.Nanomedicines can effectively enhance the biocompatibility,stability,and targeting of drugs,as well as prolong their half-life,thereby significantly improving the efficacy of traditional medications.In recent years,there has been some progress in the application of nanomaterials in the field of ischemic stroke diagnosis and treatment,although challenges in clinical translation remain.This article primarily reviews the research progress and challenges of nanomaterials in the diagnosis and treatment of ischemic stroke,aiming to further promote the research and application of nanomaterials in stroke therapy.