中国卒中杂志2024，Vol.19Issue(9)：1012-1017,6.DOI:10.3969/j.issn.1673-5765.2024.09.005
纳米材料在缺血性卒中诊疗中的研究进展及挑战
Research Progress and Challenges of Nanomaterials in the Diagnosis and Treatment of Ischemic Stroke
摘要
Abstract
Stroke is a major cause of death and long-term disability among residents in China.Traditional therapeutic drugs are limited by the obstruction of the blood-brain barrier,poor stability,lack of targeting,and low drug loading,which may result in suboptimal treatment outcomes.Nanomaterials,as an emerging,non-invasive,and real-time controllable drug delivery system,have been widely used in the diagnosis and treatment of stroke.Nanomedicines can effectively enhance the biocompatibility,stability,and targeting of drugs,as well as prolong their half-life,thereby significantly improving the efficacy of traditional medications.In recent years,there has been some progress in the application of nanomaterials in the field of ischemic stroke diagnosis and treatment,although challenges in clinical translation remain.This article primarily reviews the research progress and challenges of nanomaterials in the diagnosis and treatment of ischemic stroke,aiming to further promote the research and application of nanomaterials in stroke therapy.关键词
缺血性卒中/纳米材料/血脑屏障/靶向治疗/诊疗/挑战Key words
Ischemic stroke/Nanomaterial/Blood-brain barrier/Targeted therapy/Diagnosis and treatment/Challenge分类
医药卫生引用本文复制引用
张丽苹,曹黎明,肖楠,廖雨琦,池枫,余艳妮,任力杰..纳米材料在缺血性卒中诊疗中的研究进展及挑战[J].中国卒中杂志,2024,19(9):1012-1017,6.基金项目
广东省自然科学基金面上项目(2314050000154)深圳市优秀科技创新人才培养博士基础研究启动项目(RCBS20210609104631086)深圳市第二人民医院(深圳大学第一附属医院)"有组织医学科学研究行动计划"项目(2024YZZ01) （2314050000154）
