嗜酸性粒细胞与单核细胞比值预测急性缺血性卒中患者静脉溶栓预后的价值研究OA北大核心CSTPCD

Objective To investigate the relationship between eosinophil-to-monocyte ratio(EMR)and the prognosis of patients with acute ischemic stroke(AIS)receiving intravenous thrombolysis. Methods The clinical data of 211 patients with AIS who received intravenous thrombolysis were collected from the First Affiliated Hospital of Bengbu Medical University from January 2021 to December 2022.The patients were divided into the good prognosis(mRS score ≤2 points)group and the poor prognosis(mRS score＞2 points)group according to the mRS score after 3 months.They were divided into the survival group and the death group according to their survival status.Univariate and multivariate logistic regression analysis were used to evaluate the relationship between EMR and the prognosis of patients with AIS receiving intravenous thrombolysis.ROC curve was used to compare the prediction accuracy of EMR,neutrophil-to-lymphocyte ratio(NLR),and platelet-to-lymphocyte ratio(PLR).According to the optimal cut-off value of the ROC curve,patients were divided into the high EMR group and the low EMR group to analyze the relationship between EMR level and the prognosis. Results Multivariate logistic regression analysis showed that EMR(OR 0.406,95％CI 0.277-0.597,P＜0.001)was independently associated with poor prognosis in AIS patients receiving intravenous thrombolysis.The ROC curve showed that the AUC of EMR was 0.773(95％CI 0.711-0.836,P＜0.001),which was superior to NLR and PLR.Its optimal cut-off value was 0.435,the sensitivity was 90.2％,and the specificity was 55.8％.The poor prognosis(P＜0.001)and mortality(P=0.009)of the high EMR group(81 cases)were reduced compared to the low EMR group(130 cases). Conclusions Lower EMR was independently associated with poor prognosis at 3 months in AIS patients receiving intravenous thrombolysis.