血清组织蛋白酶L联合ABCD3-Ⅰ评分对TIA患者短期脑梗死的预测价值研究OA北大核心CSTPCD

Objective To study the value of age,blood pressure,clinical features,duration,diabetes,double transient ischemic attack,image(ABCD3-Ⅰ)score combined with serum cathepsin L(CatL)level in predicting the short-term cerebral infarction in patients with TIA. Methods The data of TIA patients admitted to the Northwest University First Hospital from October 2019 to June 2022 were retrospectively and continuously collected.The patients were divided into the cerebral infarction group and the control group according to whether acute cerebral infarction occurred at 90 d follow-up.The differences in ABCD3-Ⅰ score,serum CatL level,and clinical data between two groups of patients were compared.The independent influencing factors of short-term cerebral infarction in TIA patients were analyzed by multivariate logistic regression.The predictive value of ABCD3-Ⅰ score and serum CatL level on the occurrence of short-term cerebral infarction in TIA patients was analyzed by the ROC curve. Results A total of 115 patients with TIA were enrolled,including 22 patients in the cerebral infarction group and 93 patients in the control group.The ABCD3-Ⅰ score[7.0(6.0-7.0)points vs.5.0(4.5-6.0)points,P＜0.001],serum CatL level[(6.1±0.9)μg/L vs.(4.8±0.9)μg/L,P＜0.001],and LDL-C level[(3.6±0.5)mmol/L vs.(3.4±0.6)mmol/L,P=0.039]of the cerebral infarction group were higher than those of the control group.Multivariate logistic regression analysis showed that the elevated ABCD3-Ⅰ score(OR 4.843,95％CI 2.301-10.193,P＜0.001)and the elevated serum CatL level(OR 2.099,95％CI 1.332-3.308,P=0.001)were independent risk factors for the occurrence of acute cerebral infarction in TIA patients.ROC curve analysis showed that the AUC value of ABCD3-Ⅰ score and serum CatL level in predicting acute cerebral infarction of TIA patients were 0.829(95％CI 0.749-0.909)and 0.867(95％CI 0.796-0.938),respectively,and the corresponding cutoff value were 7.0 points and 5.3 μg/L,respectively.The AUC value of the combination of the two indicators was 0.911(95％CI 0.848-0.974). Conclusions The combination of ABCD3-Ⅰ score and serum CatL level has good predictive value on the occurrence of short-term cerebral infarction in TIA patients.