肿瘤药学2024，Vol.14Issue(4)：406-410,5.DOI:10.3969/j.issn.2095-1264.2024.04.04
帕博利珠单抗联合伊匹木单抗导致结肠癌患者免疫性脑炎的病例报告
A case report of immune encephalitis caused by pembrolizumab and ipilimumab in a colon cancer patient
程妍 1谌赟2
作者信息
- 1. 宁乡市中医医院 临床药学室,湖南 长沙,410600
- 2. 湖南省肿瘤医院 临床药学室,湖南 长沙,410013
- 折叠
摘要
Abstract
In the course of anti-tumor therapy,immune encephalitis caused by immune checkpoint inhibitors(ICI)ac-counts for a relatively low proportion of immune-related adverse events(irAE),but once it occurs,it will seriously affect the survival of patients.This article reported a colon cancer patient who was treated with pembrolizumab combined with ipilim-umab and developed neurological symptoms such as slow reaction and slurred speech on the 3rd day of treatment.After a series of examinations,immune encephalitis was considered,and methylprednisolone was administered at a dose of 2 mg·kg-1·d-1.The patient's condition improved after 14 days of treatment,and methylprednisolone was gradually tapered off until it was discontinued.The patient's relevant examination results and symptoms have returned to normal.Early diag-nosis and treatment of immune checkpoint inhibitor-related neurological adverse reactions are of great importance to the prognosis of patients.This report is of great significance for the study of immune encephalitis caused by PD-1 inhibitors and CTLA-4 inhibitors and the design of treatment regimens for this side effect.关键词
结肠癌/帕博利珠单抗/伊匹木单抗/免疫性脑炎/免疫检查点抑制剂/免疫相关不良事件Key words
Colon cancer/Pembrolizumab/Ipilimumab/Immune encephalitis/Immune checkpoint inhibitors/Immune-related adverse events分类
医药卫生引用本文复制引用
程妍,谌赟..帕博利珠单抗联合伊匹木单抗导致结肠癌患者免疫性脑炎的病例报告[J].肿瘤药学,2024,14(4):406-410,5.
