肿瘤药学2024，Vol.14Issue(4)：420-428,9.DOI:10.3969/j.issn.2095-1264.2024.04.06
小细胞肺癌治疗研究进展
Research progress in small cell lung cancer treatment
摘要
Abstract
Small cell lung cancer(SCLC)belongs to neuroendocrine malignancy and indicates an extremely poor prog-nosis.Concurrent chemoradiotherapy and first-line chemotherapy of SCLC rely on traditional medication such as etoposide and platinum,and the options after first-line treatment resistance are limited.In recent years,immunotherapy has emerged in the field of SCLC.Immunotherapy combined with chemotherapy has become the first-line standard of care for extensive-stage SCLC.ASTRUM-005 and CAPSTONE-1 studies confirmed that serplulimab and adebrelimab further prolonged the survival time of extensive-stage SCLC patients.Antivascular therapy has offered a new option for third-line or subsequent treatment of SCLC.Immunotherapy combined with antivascular therapy is advancing to the first-line treatment of exten-sive-stage SCLC,and is being explored in limited-stage SCLC.The development of limited-stage SCLC treatment has been slow.Some clinical researches on optimal timing,radiation dose and fractionation pattern of thoracic radiotherapy have made some progress.But the role of prophylactic cranial irradiation in limited-stage SCLC has been questioned by some clinical evidences.New medicine such as delta-like ligand 3(DLL3)inhibitors and poly-ADP ribose polymerase(PARP)inhibitors gradually emerged,hoping to bring new breakthroughs in the treatment of SCLC.Meanwhile,the prelimi-nary determination of molecular subtypes of SCLC is essential for precision therapy.Exploration of immunotherapy pattern in limited-stage SCLC,new immune checkpoint inhibitor medicine and different combination therapy strategies are de-signed in clinical trials for SCLC population.This review aims to summary the new advances in the treatment of SCLC.关键词
小细胞肺癌/免疫治疗/放射治疗/抗血管治疗Key words
Small cell lung cancer/Immunotherapy/Radiotherapy/Antivascular therapy分类
医药卫生引用本文复制引用
赵先国,彭文颖,蔡丽娟,杨润祥..小细胞肺癌治疗研究进展[J].肿瘤药学,2024,14(4):420-428,9.基金项目
云南省科技厅2023年度昆医联合专项面上项目(202301AY070001-254). （202301AY070001-254）
