中国中西医结合外科杂志2024，Vol.30Issue(5)：734-739,6.DOI:10.3969/j.issn.1007-6948.2024.05.025
基于网络药理学与分子对接技术探讨红芪-淫羊藿治疗骨质疏松症的作用机制
Exploring the mechanism of Radix Hedysari-Epimedium in treating osteoporosis based on network pharmacology and molecular docking technology
摘要
Abstract
Objective To explore the mechanism of treating osteoporosis with Radix Hedysari-Epimedium through network pharmacology and molecular docking technology.Methods Obtain and screen the effective active ingredients of Radix Hedysari and Epimedium on the TCMSP website,and search potential targets through the Swiss Target Prediction database.Obtaining target proteins for osteoporosis from three databases:GeneCards,DrugBank,and OMIM.Draw a Venn diagram by taking the intersection of drug related targets and disease targets,construct a"drug-component-target"network diagram,analyze proteins on the STRING data platform,construct protein interaction networks,and obtain core targets.DAVID database was used for GO enrichment and KEGG pathway annotation analysis,and molecular docking verification was conducted between the main active components and core target proteins.Results A total of 33 active ingredients and 538 targets of Radix Hedysari-Epimedium were identified,including naringenin,liquiritigenin,Epimedium A,luteolin.Some core targets were obtained,including SRC,CTNNB1,STAT3.KEGG pathway enrichment analysis showed that Radix Hedysari-Epimedium may treat osteoporosis by regulating inflammatory response,MAPK signaling pathway,and PI3K-AKT signaling pathway.The molecular docking results showed that the core active components of the drug had strong affinity with the core target proteins SRC and EGFR.Conclusion This study revealed the mechanism of multi-component,multi-target and multi-channel for Radix Hedysari-Epimedium in the treatment of osteoporosis.关键词
红芪/淫羊藿/骨质疏松症/网络药理学/分子对接Key words
Radix hedysari/epimedium/osteoporosis/network pharmacology/molecular docking分类
医药卫生引用本文复制引用
陈宇,王丽,卢嘉丽,杨丽宁,张鑫..基于网络药理学与分子对接技术探讨红芪-淫羊藿治疗骨质疏松症的作用机制[J].中国中西医结合外科杂志,2024,30(5):734-739,6.基金项目
甘肃省中医药管理局项目(GZKP-2021-19) （GZKP-2021-19）
