肿瘤药学2024，Vol.14Issue(4)：436-441,6.DOI:10.3969/j.issn.2095-1264.2024.04.08
自噬泛素样系统在肿瘤中的研究进展
Research progress of autophagy ubiquitin-like conjugation system in cancer
摘要
Abstract
Autophagy is an important cellular metabolic process,which is mainly responsible for the degradation of proteins and damaged organelles,as well as the degradation products for energy supply and protein synthesis.Autophagy is finely regulated to adapt the environment.Excessive activation or inhibition of autophagy can lead to the imbalance of autophagy level,and then lead to the development of a variety of diseases including tumors.Recent studies have shown that autophagy has a complex regulatory role in the occurrence and development of tumors and the sensitivity to radiotherapy and chemotherapy,while the key steps in the process of autophagy are strictly regulated by the autophagy ubiquitin-like conjugation system.Our review is aimed to summarize the effect of autophagy ubiquitin-like conjunction system on the occurrence and development of tumors and the sensitivity to radiotherapy and chemotherapy,so as to provide new perspectives and strategies for future tumor research based on autophagy.关键词
自噬/肿瘤/化疗敏感性/肿瘤发生Key words
Autophagy/Cancer/Chemotherapy/Tumorigenesis分类
医药卫生引用本文复制引用
文志鹏,卢慧,李琴,聂佳丽,樊兴华,李琳,杨继红,李明,郑志昌..自噬泛素样系统在肿瘤中的研究进展[J].肿瘤药学,2024,14(4):436-441,6.基金项目
国家自然科学基金地区基金(82060667) （82060667）
贵州省科技厅科技计划项目(黔科合基础-ZK[2021]一般563). （黔科合基础-ZK[2021]一般563）
