肿瘤药学2024，Vol.14Issue(4)：463-467,5.DOI:10.3969/j.issn.2095-1264.2024.04.12
吡柔比星载药微球联合洛铂在原发性肝癌介入栓塞治疗中的临床效果及不良反应分析
Clinical efficacy and adverse reactions of pirarubicin-loaded microspheres combined with lobaplatin in interventional embolization therapy for primary liver cancer
摘要
Abstract
Objective To investigate the clinical efficacy and adverse reactions of pirarubicin-loaded microspheres com-bined with lobaplatin in interventional embolization therapy for primary liver cancer.Methods A total of 92 patients with advanced primary liver cancer admitted to the First Affiliated Hospital of Hebei North University between June 2020 and June 2022 were selected in this study.Patients were assigned into the control group(n=46)and observation group(n=46)ac-cording to the random number table method.All patients were treated with interventional embolization.Patients in control group were treated by perfusion of lobaplatin,and those in observation group were treated with pirarubicin-loaded micro-spheres on the basis of the control group.The efficacy and the occurrence of adverse reactions were compared between the two groups,as well as the levels of vascular endothelial growth factor(VEGF),osteopontin(OPN),tumor necrosis factor-α(TNF-α),total bilirubin(TBil),and alanine transaminase(ALT).Results The total effective rate of the observation group(84.78%)was obviously higher than that of the control group(65.22%)(P<0.05).Compared with before treatment,the levels of VEGF,OPN,TNF-α,TBil,and ALT in the two groups were obviously reduced after treatment(P<0.05).After treatment,the levels of VEGF,OPN,TNF-α,TBil,and ALT in the observation group were obviously reduced when compared with the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion The combination of pirarubicin-loaded microspheres and lobaplatin showed a good effect in the interventional embolization therapy of primary liver cancer.It can improve the disease control rate and liver function of patients.关键词
吡柔比星/载药微球/洛铂/原发性肝癌/介入栓塞/临床效果/不良反应Key words
Pirarubicin/Drug-loaded microspheres/Lobaplatin/Primary liver cancer/Interventional embolization/Clin-ical effects/Adverse reaction分类
医药卫生引用本文复制引用
张超,戴钰辉,赵婷,袁泽龙..吡柔比星载药微球联合洛铂在原发性肝癌介入栓塞治疗中的临床效果及不良反应分析[J].肿瘤药学,2024,14(4):463-467,5.基金项目
张家口市技术创新引导计划(2121194H). （2121194H）
