中国医院用药评价与分析2024，Vol.24Issue(9)：1090-1092,1096,4.DOI:10.14009/j.issn.1672-2124.2024.09.015
苍柴调中方辅助改善肝郁脾虚型肥胖2型糖尿病的疗效及对胰岛素抵抗、FFA、LDL-C水平的影响
Efficacy of Cangchai Tiaozhong Formula in Adjuvant Treatment of Obese Type 2 Diabetes Mellitus with Liver Depression and Spleen Deficiency Syndrome and Its Effects on Insulin Resistance,FFA and LDL-C Levels
摘要
Abstract
OBJECTIVE:To probe into the efficacy of Cangchai Tiaozhong formula in adjuvant treatment of obese type 2 diabetes mellitus(T2DM)with liver depression and spleen deficiency syndrome,and to analyze the effects on insulin resistance,free fatty acids(FFA),and low density lipoprotein cholesterol(LDL-C)levels.METHODS:Totally 100 patients with T2DM admitted into the hospital from Apr.2020 to Apr.2023 were extracted to be divided into two groups through the random number table method,with 50 cases in each group.The control group was treated with metformin,while the observation group received Cangchai Tiaozhong formula on the basis of the control group.Curative effect of two groups was observed.Differences of traditional Chinese medicine symptom score,glucose metabolism index[fasting blood glucose(FBG),fasting insulin(FINS),homeostatic model assessment of insulin resistance(HOMA-IR)],serum FFA,LDL-C and tumor necrosis factor α(TNF-α)before and after treatment were compared between two groups.The incidence of adverse drug reactions was statistically analyzed.RESULTS:The total effective rate of treatment in the observation group was higher than that in the control group,and the incidence of adverse reactions was lower than that in the control group,with statistically significant difference(P<0.05).After treatment,the scores of traditional Chinese medicine symptoms in the observation group were lower than those in the control group,such as fatigue,mental depression,abdominal distension,and sticky stool,with statistically significant differences(P<0.05).Compared with before treatment,the levels of FBG,HOMA-IR and FINS in the two groups decreased significantly after treatment,and the levels of FINS,FBG and HOMA-IR in the observation group were lower than those in the control group after treatment,with statistically significant differences(P<0.05).The levels of serum LDL-C,FFA and TNF-α in the observation group were lower than those in the control group after treatment,and the differences were statistically significant(P<0.05).CONCLUSIONS:Adjuvant treatment with Cangchai Tiaozhong formula can significantly improve the therapeutic effect of obese T2DM patients with liver depression and spleen deficiency syndrome,improve insulin resistance,and down-regulate serum FFA and LDL-C levels.关键词
苍柴调中方/肥胖/2型糖尿病/胰岛素抵抗/游离脂肪酸/低密度脂蛋白胆固醇Key words
Cangchai Tiaozhong formula/Obese/Type 2 diabetes mellitus/Insulin resistance/Free fatty acids/Low density lipoprotein cholesterol分类
医药卫生引用本文复制引用
陆聆韵,张惟郁,刘兴静..苍柴调中方辅助改善肝郁脾虚型肥胖2型糖尿病的疗效及对胰岛素抵抗、FFA、LDL-C水平的影响[J].中国医院用药评价与分析,2024,24(9):1090-1092,1096,4.基金项目
上海市嘉定区卫生健康委员会中医药科研项目(No.2019-KY-ZYY-17) （No.2019-KY-ZYY-17）
