摘要
Abstract
Objective To observe the effect of combination therapy of aprepitant,dexamethasone,ondansetron and olanzapine on antiemetic efficacy and gastrointestinal symptoms in patients with lung cancer undergoing chemotherapy.Methods A total of 144 patients with lung cancer undergoing chemotherapy in Huangshan Shoukang Hospital between Jan-uary 2020 and October 2022 were included in this study.All patients received cisplatin-based chemotherapy.Patients were randomly divided into control group(72 cases)and observation group(72 cases).The control group was given dexa-methasone,ondansetron and olanzapine triple antiemetic therapy,and the observation group was added with aprepitant on the basis of the control group.The antiemetic efficiency,the incidence of induced nausea and vomiting at different stages af-ter intervention,and the control of gastrointestinal symptoms were compared between the two groups.Results The effective rate of the observation group was 91.67%,which was significantly higher than 75.00%of the control group(P<0.05).The in-cidence of induced nausea and vomiting in the observation group was lower than that in the control group in the acute stage,delayed stage,and persistent stage(P<0.05).In terms of the control of gastrointestinal symptoms,the vomiting days and the remedial antiemetic patients were less in the observation group than in the control group(P<0.05).Moreover,patients with satisfaction to antiemetic effect and the KPS scores of the observation group were more than those of the control group(P<0.05).There was no significant difference in non-chemotherapy-induced adverse reactions between the observation group and the control group(P>0.05).Conclusion The combination therapy of aprepitant,dexamethasone,ondansetron and olan-zapine was effective in the prevention of gastrointestinal symptoms such as induced nausea and vomiting in lung cancer pa-tients undergoing chemotherapy,and can improve their satisfaction to the antiemetic effect.The quadruple regimen had a good safety,for it did not increase the risk of non-chemotherapy-induce adverse reactions.关键词
诱导性恶心呕吐/肺癌化疗/阿瑞匹坦/消化道症状Key words
Induced nausea and vomiting/Lung cancer chemotherapy/Aprepitant/Gastrointestinal symptom分类
医药卫生
