中国免疫学杂志2024，Vol.40Issue(9)：1793-1802,10.DOI:10.3969/j.issn.1000-484X.2024.09.001
免疫细胞的RNA表观遗传修饰
RNA epigenetic modification of immune cells
摘要
Abstract
In recent years,the rapid advancement of biotechnology has shifted the focus of epigenetic research towards RNA modifications,which play pivotal roles across a diverse range of physiological and pathological processes,particularly in regulating the immune system.As a highly complex and precise regulatory network,the immune system involves the synergistic action of multiple im-mune cells to maintain the immune homeostasis.RNA epigenetic modification plays a crucial role in modulating the development and function of immune cells by influencing different metabolic processes of RNA.This review aims to provide a comprehensive overview of the functions and corresponding regulatory mechanisms of six RNA modifications:m6A,m1A,m5C,m7G,ac4C,and A-to-I editing in immune cells,and further explore their potential roles in complex diseases such as autoimmune diseases and tumors,in order to pro-vide new ideas and strategies for the prevention and treatment of immune-related diseases.关键词
RNA修饰/免疫细胞/转录后调控/免疫调控Key words
RNA modification/Immune cells/Post-transcriptional regulation/Immunoregulation分类
医药卫生引用本文复制引用
宋霄涵,李华兵,周静..免疫细胞的RNA表观遗传修饰[J].中国免疫学杂志,2024,40(9):1793-1802,10.基金项目
国家自然科学基金(82271756,82325024) （82271756,82325024）
重庆国际免疫研究院项目(2023YJC01) （2023YJC01）
上海市科学技术委员会项目(22QA1408100). （22QA1408100）
