鸢尾素调节PD-1/PD-L1通路增强病毒性心肌炎小鼠的抗病毒免疫水平OA北大核心CSTPCD
Iridin regulates PD-1/PD-L1 pathway and enhances antiviral immune level in mice with viral myocarditis
目的:探讨鸢尾素调节程序性死亡因子-1(PD-1)/程序性死亡因子配体-1(PD-L1)通路增强病毒性心肌炎小鼠抗病毒免疫水平的作用.方法:取50只C57BL/6小鼠经腹腔接种柯萨奇病毒B3(CVB3)构建病毒性心肌炎小鼠模型,将建模成功小鼠随机分为模型组、鸢尾素低、中、高剂量组和阳性对照组,另取10只C57BL/6小鼠记为空白对照组.阳性对照组经腹腔注射给予10 000 U/g干扰素,鸢尾素低、中、高剂量组经腹腔注射给予30、60、120 μg…查看全部>>
Objective:To investigate the effect of iridin on enhancing antiviral immune effect in mice with viral myocarditis by regulating programmed death factor-1(PD-1)/programmed death factor ligand-l(PD-L1)pathway.Methods:Fifty C57BL/6 mice were inoculated intraperitoneally with Coxsackie virus B3(CVB3)to construct mouse model of viral myocarditis.Successfully modeled mice were randomly divided into model group,iridin low,medium and high doses groups and positive c…查看全部>>
谭冠文;朱朱;周文静
河南省信阳职业技术学院,信阳 464000广东医科大学研究生学院,东莞 523800漯河市中心医院重症监护室,漯河 462000
临床医学
鸢尾素程序性死亡因子-1病毒性心肌炎抗病毒免疫
IridinPD-1Viral myocarditisAntiviral immunity
《中国免疫学杂志》 2024 (9)
1876-1882,7
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