丙泊酚靶控输注复合阿芬太尼对声带息肉摘除术患者的麻醉效果和血流动力学的影响分析OA

Objective To assess the safety and therapeutic impact of propofol target-controlled infusion combined with alfentanil for vocal polyp excision.Methods From January 2023 to January 2024,vocal polyp ectomy removal surgery patients 80 cases in Ganzhou People's Hospital's were selected and randomly assigned into group A(40 cases)and group F(40 cases).In the anesthetic induction sequence,the two subject groups in the clinical trial had their propofol plasma target concentration set at 3.5μg/ml.Rocuronium bromide was administered at a dosage of 0.6mg/kg,followed by a slow and careful injection.In group F,this was succeeded by an injection of fentanyl at 3μg/kg.In contrast,group A received an intravenous injection of alfentanil at a dosage of 20μg/kg.In both groups,tracheal intubation was executed when muscle relaxation had been achieved.Monitoring and documentation of hemodynamic fluctuations during the perioperative stages.Records were kept for the procedure's conclusion time,the time frame for regaining consciousness and extubation,and any adverse effects experienced.Results While the contrast of mean arterial pressure(MAP)and heart rate(HR)between two groups at each time point from To to T4 were statistically non-significant(P＞0.05).Compared with preoperative baseline(To),MAP and HR were lower in both groups at all time points within group at T1,T2,T3 and T4(P＜0.05),the within-group examination of these parameters across time points and their interactions did show quantifiable differences(P＜0.05).The interval from regaining consciousness to extubation was shorter in group A than that in group F(P＜0.05).Additionally,the quantity of propofol and the number of unanticipated effects were diminished in group A than those in group F(P＜0.05).Conclusion In the context of vocal polypectemy,the administration of propofol via a targeted infusion combined with alfentanil maintains hemodynamic stability,minimizes propofol dosing in contrast to fentanyl,and is linked to faster awakening times and a lower occurrence of adverse effects.