中华耳科学杂志2024，Vol.22Issue(4)：644-649,6.DOI:10.3969/j.issn.1672-2922.2024.04.023
1800MHz电磁辐射对豚鼠空间记忆及听觉系统影响的初步研究
Effects of Electromagnetic Radiation at 1800 MHz on Spatial Memory and Auditory System in Guinea Pigs
摘要
Abstract
Objective To report effects of 1800 MHz mobile phone electromagnetic radiation(EMR)on auditory thresholds,memory,and ultrastructures of the hippocampus and auditory cortex in guinea pigs.Methods Thirty-two adult guinea pigs were randomly divided into 4 groups to be exposed to 1800 MHz EMR at different specific absorption rates(SAR),i.e.0,2,4 and 10 W/kg,for 48 h.Auditory brainstem responses(ABR),Morris water maze,ELISA and transmission electron microscopy(TEM)were used to evaluate changes in hearing,spatial orientation ability,reactive oxygen species(ROS)content and ultrastructure of the hippocampus and auditory cortex,respectively.Results There was no significant change in ABR thresholds before and after exposure(P>0.05).The water maze central activity dis-tance was shortened in the 4 W/kg and 10 W/kg groups.The level of oxidative stress in exposure groups was elevated,with neuronal and mitochondrial damages observed under the TEM,especially in the 10w/kg group.Conclusions Acute exposure to 1800 MHz EMR may not affect hearing thresholds in guinea pigs,but ultrastructural damages can gradually aggravate with increased oxidative stress as radiation intensity increases,which may do harm to spatial memory abilities.关键词
电磁辐射/听性脑干反应/氧化应激/空间记忆/超微结构Key words
electromagnetic radiation/auditory brainstem response/oxidative stress/spatial memory/ultrastructure引用本文复制引用
罗小莉,左汶奇,杨红红,章碧云,钟时勋..1800MHz电磁辐射对豚鼠空间记忆及听觉系统影响的初步研究[J].中华耳科学杂志,2024,22(4):644-649,6.基金项目
重庆市自然科学基金面上项目(CSTB2024NSCQ-MSX1014) （CSTB2024NSCQ-MSX1014）
