抑制核转录因子E2相关因子2途径对高糖状态下胰腺癌细胞转移及免疫逃逸因子表达的调节作用OA北大核心CSTPCD
Inhibition of nuclear transcription factor E2-related factor 2 pathway regulates pancreatic cancer cell metastasis and immune escape factor expression under high glucose
目的:探究抑制核转录因子E2相关因子2(Nrf2)途径对高糖状态下胰腺癌细胞转移及分泌免疫逃逸因子水平的影响.方法:培养人胰腺癌细胞株Panc-1,采用5.5、10、25、50 mmol/L葡萄糖处理细胞,分别于12 h、24 h、48 h通过MTT检测细胞增殖率,24 h时通过RT-qPCR和Western blot检测细胞内Nrf2表达变化;实验分为:对照组、高糖(HG)组、Nrf2抑制剂ML385+高糖(ML385+HG)组,MTT检测细胞…查看全部>>
Objective:To investigate effect of inhibiting nuclear transcription factor-E2 related factor 2(Nrf2)pathway on metastasis and secretion of immune escape factors of pancreatic cancer cells under high glucose state.Methods:Human pancreatic cancer cell line Panc-1 was cultured,and treated with 5.5,10,25 and 50 mmol/L glucose.Cell proliferation rate was detected by MTT at 12 h,24 h and 48 h,respectively,and at 24 h,changes of intracellular Nrf2 expression were d…查看全部>>
唐津天;唐润娟;薛峰;黎旺红
新疆医科大学附属肿瘤医院肝胆胰外科二病区,乌鲁木齐 830054新疆医科大学第二附属医院康复科,乌鲁木齐 830028新疆医科大学附属肿瘤医院肝胆胰外科二病区,乌鲁木齐 830054新疆医科大学附属肿瘤医院肝胆胰外科二病区,乌鲁木齐 830054
临床医学
胰腺癌高糖核转录因子E2相关因子2免疫逃逸因子
Pancreatic cancerHigh glucoseNuclear transcription factor E2-related factor 2Immune escape factor
《中国免疫学杂志》 2024 (9)
1883-1888,6
新疆维吾尔自治区自然科学基金(2021D01C399).
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