中华耳科学杂志2024，Vol.22Issue(4)：650-654,5.DOI:10.3969/j.issn.1672-2922.2024.04.024
衰老耳蜗带状突触中的蛋白质稳态
Proteostasis at Ribbon Synapses in Aging Cochlea
摘要
Abstract
The cochlear ribbon synapse is a crucial afferent structure for auditory information conversion and con-duction,with special molecular expression.And this synapse has been described as an early-onset point in an aging co-chlea.Previous studies have demonstrated that proteostasis is of great significance to aging changes,also true in cochle-ar aging.In this paper,we provide insights into the two major protein degradation pathways,i.e.the ubiquitin-protea-some system(UPS)and the autophagy-lysosome pathway(ALP),respectively,which are critical mechanisms for clear-ing misfolded or unfolded proteins.Studies on dysregulation of protein degradation mechanisms have revealed the influ-ences of protein homeostasis on synaptic lesions in the aging cochlea.Therefore,regulating protein homeostasis may of-fer considerable and potential possibilities to treat age-related hearing loss.关键词
耳蜗带状突触/衰老/蛋白质稳态/泛素-蛋白酶系统/自噬-溶酶体途径Key words
cochlear ribbon synapse/aging/proteostasis/ubiquitin-proteasome system/autophagy-lysosome pathway引用本文复制引用
蔡玮,卢春键,谢慧..衰老耳蜗带状突触中的蛋白质稳态[J].中华耳科学杂志,2024,22(4):650-654,5.基金项目
四川省科技厅科技创新基地和人才计划项目(2022JD-KP0018) （2022JD-KP0018）
