中国现代医生2024，Vol.62Issue(26)：29-32,37,5.DOI:10.3969/j.issn.1673-9701.2024.26.007
低分子肝素钙联合前列地尔在甲状腺术后甲状旁腺功能减退治疗中的应用
Low-molecular-weight heparin calcium with application of alprostadil combined in the treatment of hypoparathyroidism after thyroid surgery
摘要
Abstract
Objective To investigate the application value of low-molecular-weight heparin calcium combined with alprostadil in the treatment of hypoparathyroidism(HP)after thyroid surgery.Methods Sixty patients with HP after thyroid surgery were randomly divided into two groups:study group(30 cases)and control group(30 cases).The study group received low-molecular-weight heparin calcium and alprostadil,along with oral calcium supplements and calcitriol or an intravenous infusion of calcium gluconate,for three consecutive days after surgery.The control group received only oral calcium supplements and calcitriol or intravenous calcium gluconate.The values and changes in parathyroid hormone(PTH),postoperative drainage volume,and postoperative complications were compared between two groups.Results There were no significant difference in PTH levels at 3 days,1 week,1 month,and 6 months after surgery between two groups(P＞0.05).The difference in PTH levels between 3 days and 1 day after surgery was(6.77±2.61)ng/L in study group and(1.29±1.12)ng/L in control group,with a significant difference(P＜0.05).The difference in PTH levels between 1 week and 1 day after surgery was(10.51±3.66)ng/L in study group and(2.65±2.17)ng/L in control group(P＜0.05).There were no significant difference in PTH levels at 1 month,6 months,and 1 day after surgery(P＞0.05).Comparison of postoperative drainage volume:The postoperative drainage volume of study group was(90.07±22.24)ml,and that of control group was(88.20±24.09)ml,with no statistical significance(P＞0.05).There was no significant difference in postoperative complications between two groups(P＞0.05).Conclusion In cases of HP after total thyroidectomy,timely use of low-molecular-weight heparin calcium and alprostadil can accelerate the recovery of PTH and reduce patient numbness,which is safe,effective,and worthy of clinical promotion.关键词
甲状腺手术/甲状旁腺功能减退/低分子肝素钙/前列地尔Key words
Thyroid surgery/Hypoparathyroidism/Low-molecular-weight heparin calcium/Alprostadil分类
医药卫生引用本文复制引用
俞建平,何春,彭云,文玉忠,肖锡岗..低分子肝素钙联合前列地尔在甲状腺术后甲状旁腺功能减退治疗中的应用[J].中国现代医生,2024,62(26):29-32,37,5.基金项目
江西省卫生健康委员会科技计划项目(202212466) （202212466）
