中华耳科学杂志2024，Vol.22Issue(4)：661-665,5.DOI:10.3969/j.issn.1672-2922.2024.04.026
Hippo/Yap信号通路在调控听觉和前庭系统中的研究进展
Progress of Research on Hippo/Yap Signaling Pathway in Regulation of Auditory System
摘要
Abstract
The Hippo/Yap signaling pathway is extensively implicated in auditory system development,hearing injury repair,and auditory system disorders.The regulation of Yap during embryonic development may result in mor-phological and functional defects of the hearing organ.The Hippo/Yap signaling pathway is involved in processes relat-ed to hearing system injury and diseases by interacting with a wide range of signaling molecules,which are influenced by the JNK signaling pathway,the Wnt signaling system,and mechanical signal transduction.This review covers the de-velopment in Hippo/Yap signaling pathway research in regard to the auditory system,to hopefully provide novel ideas for understanding the molecular biological process and developing therapeutic therapies for various forms of hearing loss.关键词
Hippo/Yap信号/听力损失/毛细胞再生/听力保护Key words
Hippo/Yap signaling/hearing loss/HCs regeneration/hearing protection引用本文复制引用
郝文丽,俞晨杰,程诚,卢洁,邱悦,吉欣雅,钱晓云,高下..Hippo/Yap信号通路在调控听觉和前庭系统中的研究进展[J].中华耳科学杂志,2024,22(4):661-665,5.基金项目
国家自然科学基金资助项目:82271173 （）
