中国中医药信息杂志2024，Vol.31Issue(10)：19-23,5.DOI:10.19879/j.cnki.1005-5304.202403054
基于中医阴阳学说探讨巨噬细胞极化在糖尿病肾脏疾病中的作用
Discussion on the Effects of Macrophage Polarization on Diabetic Kidney Disease Based on TCM Yin-yang Theory
摘要
Abstract
Diabetic kidney disease(DKD)is one of the serious microvascular complications of diabetes.Immune disorder-mediated chronic inflammation is an essential mechanism underlying the occurrence of DKD.Macrophages,as important participants in the immune-inflammatory response,can polarize into the pro-inflammatory M1 phenotype and anti-inflammatory M2 phenotype under different microenvironments.The two are functionally antagonistic to each other.They can be transformed into each other in different developmental stages of DKD,which is similar to the connotation of yin and yang in the theory of"yin-yang theory"in TCM,such as restriction of opposites,mutual root and mutual use,balance of growth and decline,and mutual transformation.The imbalance of M1 and M2 macrophages is an important factor leading to DKD inflammatory response and renal fibrosis.Therefore,based on the yin-yang theory in TCM,this article clarified the effects of macrophage polarization on DKD,and proposed that the basic treatment method is to"tonify deficiency and damage excess"to adjust the polarization of macrophages and restore the balance of yin and yang,in order to provide ideas for the clinical treatment of DKD.关键词
巨噬细胞极化/糖尿病肾脏疾病/阴阳学说Key words
macrophage polarization/diabetic kidney disease/yin-yang theory分类
医药卫生引用本文复制引用
朱玲玲,谭莹,佘云,余江毅,严倩华..基于中医阴阳学说探讨巨噬细胞极化在糖尿病肾脏疾病中的作用[J].中国中医药信息杂志,2024,31(10):19-23,5.基金项目
国家自然科学基金(82004286) （82004286）
江苏省中医药管理局项目(ZT202206) （ZT202206）
江苏省研究生实践创新计划项目(SJCX23_0873) （SJCX23_0873）
