中华耳科学杂志2024，Vol.22Issue(4)：674-678,5.DOI:10.3969/j.issn.1672-2922.2024.04.029
前庭性偏头痛与脑肠轴相关性探讨
Potential Correlations between Vestibular Migraine and Brain-Gut Axis
摘要
Abstract
Vestibular migraine(VM)is a common clinical disorder with vertigo as the main manifestation,and ab-normal trigeminal-vascular function is one of the main mechanisms in its pathogenesis.Activation of the trigeminal-vas-cular system to trigger an abnormal connection between trigeminal pain inputs and the vestibular nucleus is the core of this doctrine.The brain-gut axis(GBA)is involved in the pathogenesis of VM by influencing trigeminal-vascular func-tion via four pathways:vagal,neuroendocrine,immune and gut microbial.Stress,inflammatory mediators or other exter-nal stimuli may trigger central sensitization and activation of the trigeminal-vascular system through the GBA pathway in the presence of immune cells,such as mast cells,astrocytes and satellite glial cells,and transmitter molecules,such as glutamate,acetylcholine and serotonin,as well as gut microorganisms,can affect vestibulo-nuclei neurons via synapses,potentially contributing to the onset of VM.This paper contributes to further insight into the pathophysiological mecha-nisms of VM by investigating the correlation between VM and GBA at the trigeminal-vascular level.关键词
前庭性偏头痛/脑肠轴/三叉神经血管系统/肠道微生物/中枢敏化/三叉神经-血管学说Key words
vestibular migraine/brain-gut axis/trigeminal vascular neurons/gut microbes/central sensitization/trigeminal-vascular theory引用本文复制引用
刘俊宏,王理想,王伟涛,张道培,张怀亮..前庭性偏头痛与脑肠轴相关性探讨[J].中华耳科学杂志,2024,22(4):674-678,5.基金项目
张怀亮全国名老中医药专家传承工作室建设项目(国中医药人教函[2018]134号) （国中医药人教函[2018]134号）
河南省中医药科学研究专项(2018JDZX012) （2018JDZX012）
吴阶平医学基金会(320.6750.18326) （320.6750.18326）
