中华耳科学杂志2024，Vol.22Issue(4)：679-683,5.DOI:10.3969/j.issn.1672-2922.2024.04.030
SOX10基因在神经嵴衍生细胞发育中的作用
Roles of SOX10 Gene in Neural Crest-Derived Cells Development
摘要
Abstract
The SOX10(SRY-box 10)gene belongs to the SOX(SRY-related HMG-box)transcription factor fami-ly,and is characterized by HMG(high mobility group)boxes that mediate the binding of Sox proteins to DNA.Neural crest cells(NCCs)are migratory pluripotent cells that differentiate into many cell types throughout their development,including vestibular cochlear glial cells in the inner ear,glial cells of the nervous system,melanocytes in the skin,bone and connective tissue cells in the craniofacial complex,and smooth muscle cells in the cardiovascular system.The SOX10 is necessary for the maintenance of the pluripotency of NCCs and the survival of neural crest-derived cells.The SOX10 gene regulates inner ear development in a variety of ways by participating in the development of neural crest-de-rived cells.This paper reviews relevant literatures on the roles of SOX10 in the development of neural crest-derived cells,in order to further understand its regulatory mechanisms in inner ear development,so as to better intervene in syn-dromic deafness caused by SOX10 mutations.关键词
SOX10基因/神经嵴衍生细胞/内耳发育/调控机制Key words
SOX10 gene/neural crest-derived cells/inner ear development/governance mechanism引用本文复制引用
赵亚楠,庞秀红..SOX10基因在神经嵴衍生细胞发育中的作用[J].中华耳科学杂志,2024,22(4):679-683,5.基金项目
江苏省卫生健康委科研课题(M2022067) （M2022067）
泰州市科技支撑(社会发展)项目(TS202214) （社会发展）
国家自然科学基金青年基金(81700920) （81700920）
江苏省基础研究计划(自然科学基金)面上项目(BK20191229) （自然科学基金）
江苏省第五期"333工程"科研项目(BRA2019192) （BRA2019192）
