中国中医药信息杂志2024，Vol.31Issue(10)：24-30,7.DOI:10.19879/j.cnki.1005-5304.202310061
基于数据挖掘的朴炳奎治疗大肠癌术后用药规律研究
Study on the Medication Law of Postoperative Treatment of Colorectal Cancer by Piao Bingkui Based on Data Mining
摘要
Abstract
Objective To study the medication law of postoperative treatment of colorectal cancer by national TCM doctor Professor Piao Bingkui.Methods Professor Piao Bingkui's electronic medical records and paper medical records of colorectal cancer postoperative patients at Guang'anmen Hospital,China Academy of Chinese Medical Sciences and Beijing Yiqingtang Chinese Medicine Clinic were collected and organized from their outpatients from January 1st,2002 to February 28th,2022.R4.2.1 was used to study the prescriptions,including high-frequency drugs,drug types,properties of Chinese materia medica,yin yang and five elements and dosage of drugs,as well as the law of multi-drug association in postoperative patients with colorectal cancer.Results Totally 642 colorectal postoperative cancer patients were included,involving 2 226 prescriptions,180 kinds of Chinese materia medica,and a total frequency of 39 988 times.The high-frequency drugs were Astragali Radix,fried Aurantii Fructus with wheat bran,Dioscoreae Rhizoma,etc.The main drugs in terms of efficacy were tonics for tonifying deficiency,disinfectants,etc.;the main properties were warm and neutral,the main tastes were sweet,pungent and bitter,and the main meridians were spleen meridians and stomach meridians.Ascending medicines were often used,and the drug were basically non-toxic.The frequency of using yang tonifying medicine was high,and the five elements were commonly used as local medicines;the dosage was mostly 10,15 and 20 g.The complex network analysis and clustering analysis of the association between multiple drugs found that Professor Piao Bingkui's basic prescription for treating colorectal cancer included Astragali Radix,fried Aurantii Fructus with wheat bran,Dioscoreae Rhizoma,salt Alpiniae Oxyphyllae Fructus,Citri Reticulatae Pericarpium,Smilacis Glabrae Rhizoma,Pseudostellariae Radix,and fried Atractylodis Macrocephalae Rhizoma with wheat bran.Conclusion In the treatment of colorectal cancer,Professor Piao Bingkui focuses on reinforcing the healthy qi,nourishing spleen and stomach function,combined with detoxication method and clearing heat,expelling phlegm and dampness,guiding stagnation and dispelling stasis methods,making syndrome differentiation as well as tonifying and benefiting qi,regulating qi movement,so as to realize the"treating middle-energizer as balance"and achieve mild level when treating colorectal cancer.关键词
朴炳奎/数据挖掘/大肠癌/用药规律/扶正祛邪/补中益气Key words
Piao Bingkui/data mining/colorectal cancer/medication law/reinforce the healthy qi to eliminate pathogenic factors/strengthen the middle-energizer to reinforce qi分类
医药卫生引用本文复制引用
陈欣,谢飞彪,张润顺,高劲,于惠博,马苏苏,郑红刚,花宝金..基于数据挖掘的朴炳奎治疗大肠癌术后用药规律研究[J].中国中医药信息杂志,2024,31(10):24-30,7.基金项目
国家自然科学基金面上项目(82174463、82174464) （82174463、82174464）
中央高水平中医医院临床研究和成果转化能力提升项目(HLCMHPP20230) （HLCMHPP20230）
北京市自然科学基金面上项目(7172186) （7172186）
