中国现代医生2024，Vol.62Issue(26)：76-79,4.DOI:10.3969/j.issn.1673-9701.2024.26.018
乌拉地尔联合重组人脑利钠肽治疗高血压并发急性心力衰竭的效果分析
Effect analysis of urapidil and recombinant human brain natriuretic peptide in the treatment of high blood pressure complicated with acute heart failure
摘要
Abstract
Objective To explore the clinical effect of urapidil combined with recombinant human brain natriuretic peptide(rhBNP)in the treatment of high blood pressure complicated with acute heart failure.Methods Sixty patients with high blood pressure(HBP)and acute heart failure(AHF)were collected from May 2022 to December 2023 in the inpatient department of Yingtan People's Hospital were to conduct retrospective analysis.They were divided into two groups according to different clinical drugs,with 30 cases in each group.The control group received conventional drugs(amlodipine besylate+spirolactone)+intravenous furosemide infusion+administer urapidil intravenously,the experimental group was additionally given rhBNP.Both groups received treatment for 7 days in the hospital.Blood pressure,heart rate,N-terminal pro-brain natriuretic peptide(NT-proBNP),left heart function changes and adverse reactions during treatment were compared in two groups.Results After the treatment of those patients,the total effective rate and left ventricular ejection fraction of experimental group were higher than those of control group(P＜0.05).The changes of heart rate,NT-proBNP,left ventricular end-systolic diameter,left ventricular end-diastolic diameter and blood pressure in experimental group were lower than those in control group(P＜0.05).Two groups were no significant difference in the total incidence of adverse drug reactions(P＞0.05).Conclusion Urapidil and rhBNP is obviously superior to urapidil alone in the treatment of HBP complicated with AHF,and can obviously reduce blood pressure and heart rate,improve cardiacfunction,and is safe in clinical application.关键词
急性心力衰竭/高血压/乌拉地尔/重组人脑利钠肽Key words
Acute heart failure/High blood pressure/Urapidil/Recombinant human brain natriuretic peptide分类
临床医学引用本文复制引用
祝风涛,熊君,熊枫,龚亚欣,童金英..乌拉地尔联合重组人脑利钠肽治疗高血压并发急性心力衰竭的效果分析[J].中国现代医生,2024,62(26):76-79,4.基金项目
江西省研究生创新专项项目(YC2023-S193) （YC2023-S193）
