中国现代医生2024，Vol.62Issue(27)：1-5,30,6.DOI:10.3969/j.issn.1673-9701.2024.27.001
乳酸/白蛋白和C反应蛋白对脓毒症患者90d死亡风险的预测价值
Predictive value of lactate/albumin and C-reactive protein for 90-day mortality risk in patients with sepsis
摘要
Abstract
Objective To investigate the predictive value of lactate/albumin(L/A)and C-reactive protein(CRP)for 90-day mortality risk in patients with sepsis.Methods Clinical data from 125 patients diagnosed with sepsis in the Comprehensive Intensive Care Unit,Jinhua People's Hospital from February 2021 to February 2024 retrospectively were collected.According to 90-day death or not of patients,they were divided into death group(n=61)and survival group(n=64).Independent risk factors for 90-day mortality in patients with sepsis were analyzed by using multivariate Logistic regression.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of L/A,CRP,and L/A combined CRP for 90-day mortality in patients with sepsis.At the same time,subgroup analysis of patients was performed according to the best cut-off value,and Kaplan-Meier survival curves were drawn.Results Multivariate Logistic regression analysis showed that high CRP(OR=1.009,95％CI:1.003-1.015,P=0.006),high L/A(OR=1.449,95％CI:1.050-2.000,P=0.024),and concurrent acute kidney injury(OR=2.890,95％CI:1.198-6.975,P=0.018)were independent risk factors for 90-day mortality in patients with sepsis.Area under the curve(AUC)for predicting 90-day mortality in patients with sepsis by using CRP,L/A,and L/A combined with CRP were 0.645,0.612 and 0.708 respectively.Subgroup analysis showed that 90-day mortality of patients with sepsis in L/A＞1.41 group was significantly higher than that in L/A≤1.41 group(P=0.001),and 90-day mortality of patients with sepsis in CRP＞93.29mg/L group was significantly higher than that in CRP≤93.29mg/L group(P=0.001),which was consistent with the analysis results of Kaplan-Meier survival curve.Conclusion Both L/A and CRP have certain predictive value for 90-day prognosis of patients with sepsis,and their combined predictive effect is better.关键词
乳酸/白蛋白/C反应蛋白/脓毒症/死亡风险/预测价值Key words
Lactate/albumin/C-reactive protein/Sepsis/Mortality risk/Predictive value分类
医药卫生引用本文复制引用
杜晓露,詹亚胜,项美姣..乳酸/白蛋白和C反应蛋白对脓毒症患者90d死亡风险的预测价值[J].中国现代医生,2024,62(27):1-5,30,6.基金项目
浙江省金华市科学技术研究计划项目(2021-4-070) （2021-4-070）
