中外医学研究2024，Vol.22Issue(26)：180-184,5.DOI:10.14033/j.cnki.cfmr.2024.26.046
子痫前期中关于免疫机制的最新研究进展
Latest Research Progress on Immune Mechanism in Preeclampsia
潘心辰 1孔祥1
作者信息
- 1. 扬州大学医学院 江苏 扬州 225000
- 折叠
摘要
Abstract
Preeclampsia is a common obstetric disease leading to severe maternal and maternal complications,and its etiology and pathogenesis have not been defined.Placental ischemia and hypoxia is one of the most important pathophysiological mechanisms.The maternal-fetal interface recruits many immune cells,and the innate immunity and adaptive immunity jointly participate in the immune tolerance at the maternal-fetal interface,and regulate the immune response through immune cells,cytokines,etc.The break of immune tolerance and immune imbalance cause abnormal inflammation,which causes the insufficient trophoblast cell invasion and the disorder of spiral artery remodeling,leading to placental ischemia and hypoxia.Interleukin-9(IL-9)and interleukin-27(IL-27)are recently discovered immune cytokines,which are involved in the immune regulation and other pathological mechanisms of preeclampsia.This article mainly summarized the latest research progress on the immune mechanism and related immune factors of preeclampsia in recent years.关键词
子痫前期/免疫耐受/固有免疫/适应性免疫/白细胞介素-9/白细胞介素-27Key words
Preeclampsia/Immune tolerance/Innate immunity/Adaptive immunity/Interleukin-9/Interleukin-27引用本文复制引用
潘心辰,孔祥..子痫前期中关于免疫机制的最新研究进展[J].中外医学研究,2024,22(26):180-184,5.
