中国现代医生2024，Vol.62Issue(27)：31-33,56,4.DOI:10.3969/j.issn.1673-9701.2024.27.007
杭州某医院高脂血症患者ApoE基因分析
Analysis of ApoE gene in patients with hyperlipidemia in a hospital in Hangzhou
摘要
Abstract
Objective To explore the polymorphism and distribution of apolipoprotein E(ApoE)gene in patients with hyperlipidemia.Methods A total of 370 hyperlipidemia patients diagnosed at Hangzhou Ninth People's Hospital from October 2023 to June 2024 were selected.Gene polymorphism was detected in the blood samples of the patients using fluorescence polymerase chain reaction,and the distribution of gene polymorphism among different genders and age groups within this population was compared.Results ①The polymorphism distribution of the two genetic loci(ApoE 388T＞C and ApoE 526C＞T)in the studied sample population conforms to Hardy-Weinberg equilibrium,indicating that it is representative of the population;②Among the 370 patients,the distribution of the ApoE gene was as follows:E3/E3(66.49％),E3/E4(20.27％),E2/E3(8.65％),E2/E4(1.89％),E2/E2(1.35％),and E4/E4(1.35％).The proportion of the patient population carrying the E4 allele was about 1.88 times higher than that of those carrying the E2 allele;③The distribution differences of ApoE gene polymorphism were not related to the patients'gender and age(P＞0.05).Conclusion The distribution of ApoE gene polymorphism among hyperlipidemia patients at a hospital in Hangzhou is uneven and is not related to gender or age groups.Therefore,it is recommended to prioritize the detection of ApoE gene in patients before using statin medications to assess treatment effectiveness.关键词
ApoE/基因多态性/他汀类药物/高脂血症Key words
Apolipoprotein E/Gene polymorphism/Statins/Hyperlipidaemia分类
医药卫生引用本文复制引用
杨露森,倪红妙,朱泽华,方丽娟..杭州某医院高脂血症患者ApoE基因分析[J].中国现代医生,2024,62(27):31-33,56,4.基金项目
浙江省杭州市生物医药和健康产业发展扶持科技专项(第十期)(2023WJC220) （第十期）
