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Insights into the interplay between gut microbiota and lipid metabolism in the obesity management of canines and felinesOACSTPCD

中文摘要

Obesity is a prevalent chronic disease that has significant negative impacts on humans and our companion animals,including dogs and cats.Obesity occurs with multiple comorbidities,such as diabetes,hypertension,heart disease and osteoarthritis in dogs and cats.A direct link between lipid metabolism dysregulation and obesity-associated diseases has been implicated.However,the understanding of such pathophysiology in companion animals is lim-ited.This review aims to address the role of lipid metabolism in various metabolic disorders associated with obesity,emphasizing the involvement of the gut microbiota.Furthermore,we also discuss the management of obesity,including approaches like nutritional interventions,thus providing novel insights into obesity prevention and treatment for canines and felines.

Kaiqi Li;Xiangyu Xiao;Yuling Li;Sichen Lu;Jianghang Zi;Xiaoqiang Sun;Jia Xu;Hao‑Yu Liu;Xiaoqiong Li;Tongxing Song;Demin Cai;

Laboratory of Animal Physiology and Molecular Nutrition,Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design,College of Animal Science and Technology,Yangzhou University,Yangzhou 225009,ChinaCollege of Animal Science and Technology,Huazhong Agricultural University,Wuhan 430070,ChinaSchool of Life Science and Engineering,Foshan University,Foshan 528231,China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‑Products,Institute of Food Science,Zhejiang Academy of Agricultural Sciences,Hangzhou,Zhejiang 310021,People’s Republic of ChinaCollege of Agriculture,Jinhua Polytechnic,Jinhua 321017,ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‑Products,Institute of Food Science,Zhejiang Academy of Agricultural Sciences,Hangzhou,Zhejiang 310021,People’s Republic of China

畜牧业

CatDogGut microbiotaLipid metabolismObesity Management

《Journal of Animal Science and Biotechnology》 2024 (005)

P.1761-1777 / 17

funded by research grants from the Jiangsu Provincial Double-Innovation Team Program(JSSCTD202147);Nutrition and Care of Maternal and Child Research Fund Project of the Biostime Institute of Nutrition and Care(Grant No.2022BINCMCF006);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_3527);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).

10.1186/s40104-024-01073-w

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