首页|期刊导航|Neural Regeneration Research|Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

Yujia Liu Xue Han Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia

Neural Regeneration Research2025，Vol.20Issue(9)：P.2727-2736,10.

Neural Regeneration Research2025，Vol.20Issue(9)：P.2727-2736,10.DOI:10.4103/NRR.NRR-D-23-01233

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

Yujia Liu ¹Xue Han ²Yan Su ²Yiming Zhou ²Minhui Xu ³Jiyan Xu ²Zhengliang Ma ⁴Xiaoping Gu ⁴Tianjiao Xia³

作者信息

1. Department of Anesthesiology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu Province,China Medical School,Nanjing University,Nanjing,Jiangsu Province,China Jiangsu Key Laboratory of Molecular Medicine,Nanjing University,Nanjing,Jiangsu Province,China State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing,Jiangsu Province,China Department of Anesthesiology,Zhongshan Hospital,Fudan University,Shanghai,China
2. Department of Anesthesiology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu Province,China Medical School,Nanjing University,Nanjing,Jiangsu Province,China Jiangsu Key Laboratory of Molecular Medicine,Nanjing University,Nanjing,Jiangsu Province,China State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing,Jiangsu Province,China
3. Medical School,Nanjing University,Nanjing,Jiangsu Province,China Jiangsu Key Laboratory of Molecular Medicine,Nanjing University,Nanjing,Jiangsu Province,China State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing,Jiangsu Province,China
4. Department of Anesthesiology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu Province,China
折叠

摘要

关键词

Chil1/hippocampus/learning and memory/M2 microglia/neuroinflammation/postoperative cognitive dysfunction(POCD)/recombinant CHI3L1

分类

医药卫生

引用本文复制引用

Yujia Liu,Xue Han,Yan Su,Yiming Zhou,Minhui Xu,Jiyan Xu,Zhengliang Ma,Xiaoping Gu,Tianjiao Xia..Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice[J].Neural Regeneration Research,2025,20(9):P.2727-2736,10.

基金项目

supported by the National Natural Science Foundation of China,Nos.81730033,82171193(to XG) （to XG）

the Key Talent Project for Strengthening Health during the 13~(th)Five-Year Plan Period,No.ZDRCA2016069(to XG) （th）

the National Key R&D Program of China,No.2018YFC2001901(to XG) （to XG）

Jiangsu Provincial Medical Key Discipline,No.ZDXK202232(to XG)。（to XG）

Neural Regeneration Research

ISSN：1673-5374

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